Phasing out the bad—How SQSTM1/p62 sequesters ubiquitinated proteins for degradation by autophagy

The degradation of misfolded, ubiquitinated proteins is essential for cellular homeostasis. These proteins are primarily degraded by the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy serves as a backup mechanism when the UPS is overloaded. How autophagy and the UPS are coordinated i...

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Detalles Bibliográficos
Autores principales: Zaffagnini, Gabriele, Savova, Adriana, Danieli, Alberto, Romanov, Julia, Tremel, Shirley, Ebner, Michael, Peterbauer, Thomas, Sztacho, Martin, Trapannone, Riccardo, Tarafder, Abul K., Sachse, Carsten, Martens, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103668/
https://www.ncbi.nlm.nih.gov/pubmed/29929426
http://dx.doi.org/10.1080/15548627.2018.1462079

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