An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function

Tryptophanyl-tRNA synthetase (TrpRS) in vertebrates contains a N-terminal extension in front of the catalytic core. Proteolytic removal of the N-terminal 93 amino acids gives rise to T2-TrpRS, which has potent anti-angiogenic activity mediated through its extracellular interaction with VE-cadherin....

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Detalles Bibliográficos
Autores principales: Xu, Xiaoling, Zhou, Huihao, Zhou, Quansheng, Hong, Fei, Vo, My-Nuong, Niu, Wanqiang, Wang, Zhiguo, Xiong, Xiaolin, Nakamura, Kanaha, Wakasugi, Keisuke, Schimmel, Paul, Yang, Xiang-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper - Solicited
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103731/
https://www.ncbi.nlm.nih.gov/pubmed/28910573
http://dx.doi.org/10.1080/15476286.2017.1377868

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