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Sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis

BACKGROUND: Previous cohort studies investigating the association between sarcopenia and the risk of hospitalization have been inconsistent. We performed a meta-analysis to determine if sarcopenia is a predictor of hospitalization. METHODS: Prospective cohort studies that evaluated the association b...

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Autores principales: Zhang, Xiaoming, Zhang, Wenwu, Wang, Conghua, Tao, Wuyuan, Dou, Qingli, Yang, Yunzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103964/
https://www.ncbi.nlm.nih.gov/pubmed/30134867
http://dx.doi.org/10.1186/s12877-018-0878-0
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author Zhang, Xiaoming
Zhang, Wenwu
Wang, Conghua
Tao, Wuyuan
Dou, Qingli
Yang, Yunzhi
author_facet Zhang, Xiaoming
Zhang, Wenwu
Wang, Conghua
Tao, Wuyuan
Dou, Qingli
Yang, Yunzhi
author_sort Zhang, Xiaoming
collection PubMed
description BACKGROUND: Previous cohort studies investigating the association between sarcopenia and the risk of hospitalization have been inconsistent. We performed a meta-analysis to determine if sarcopenia is a predictor of hospitalization. METHODS: Prospective cohort studies that evaluated the association between sarcopenia and hospitalization in older people were identified via a systematic search of four electronic databases (PubMed, EMBASE, Science Citation Index, and the Cochrane Library). A random-effect model was applied to combine the results according to the heterogeneity of the included studies. RESULTS: Five studies (2832 participants) were included in this meta-analysis. Pooled results demonstrated that older people with sarcopenia were at an increased risk of hospitalization (pooled hazards ratio [HR] = 1.57, 95% confidence interval [CI] = 1.26, 1.94, I(2) = 4.5%, P = 0.000) compared to those without sarcopenia. Results of subgroup analyses showed that hospitalized patients with sarcopenia had a higher rate of hospitalization (HR = 2.01, 95% CI = 1.41, 2.88, p = 0.000) versus patients without sarcopenia. A similar result was also found in community-dwelling older people with sarcopenia versus those without sarcopenia (HR = 1.40, 95% CI = 1.05, 1.88, p = 0.023). In addition, the subgroup analysis for length of follow-up showed that studies with a follow-up period of 3 years or more (pooled HR = 1.52, 95% CI = 1.19, 1.94, P = 0.001) reported a significantly higher rate of hospitalization among individuals with sarcopenia compared to those without sarcopenia. However, this association was not found in the studies with a follow-up period of less than 3 years (pooled HR = 1.76, 95% CI = 0.90, 3.44, P = 0.099). CONCLUSIONS: Sarcopenia is a significant predictor of hospitalization among older individuals, and the association may not be significantly affected by the characteristics of the population or the definition of sarcopenia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12877-018-0878-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-61039642018-08-30 Sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis Zhang, Xiaoming Zhang, Wenwu Wang, Conghua Tao, Wuyuan Dou, Qingli Yang, Yunzhi BMC Geriatr Research Article BACKGROUND: Previous cohort studies investigating the association between sarcopenia and the risk of hospitalization have been inconsistent. We performed a meta-analysis to determine if sarcopenia is a predictor of hospitalization. METHODS: Prospective cohort studies that evaluated the association between sarcopenia and hospitalization in older people were identified via a systematic search of four electronic databases (PubMed, EMBASE, Science Citation Index, and the Cochrane Library). A random-effect model was applied to combine the results according to the heterogeneity of the included studies. RESULTS: Five studies (2832 participants) were included in this meta-analysis. Pooled results demonstrated that older people with sarcopenia were at an increased risk of hospitalization (pooled hazards ratio [HR] = 1.57, 95% confidence interval [CI] = 1.26, 1.94, I(2) = 4.5%, P = 0.000) compared to those without sarcopenia. Results of subgroup analyses showed that hospitalized patients with sarcopenia had a higher rate of hospitalization (HR = 2.01, 95% CI = 1.41, 2.88, p = 0.000) versus patients without sarcopenia. A similar result was also found in community-dwelling older people with sarcopenia versus those without sarcopenia (HR = 1.40, 95% CI = 1.05, 1.88, p = 0.023). In addition, the subgroup analysis for length of follow-up showed that studies with a follow-up period of 3 years or more (pooled HR = 1.52, 95% CI = 1.19, 1.94, P = 0.001) reported a significantly higher rate of hospitalization among individuals with sarcopenia compared to those without sarcopenia. However, this association was not found in the studies with a follow-up period of less than 3 years (pooled HR = 1.76, 95% CI = 0.90, 3.44, P = 0.099). CONCLUSIONS: Sarcopenia is a significant predictor of hospitalization among older individuals, and the association may not be significantly affected by the characteristics of the population or the definition of sarcopenia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12877-018-0878-0) contains supplementary material, which is available to authorized users. BioMed Central 2018-08-22 /pmc/articles/PMC6103964/ /pubmed/30134867 http://dx.doi.org/10.1186/s12877-018-0878-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhang, Xiaoming
Zhang, Wenwu
Wang, Conghua
Tao, Wuyuan
Dou, Qingli
Yang, Yunzhi
Sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis
title Sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis
title_full Sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis
title_fullStr Sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis
title_full_unstemmed Sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis
title_short Sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis
title_sort sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103964/
https://www.ncbi.nlm.nih.gov/pubmed/30134867
http://dx.doi.org/10.1186/s12877-018-0878-0
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