Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells

The concept that human cancer is in essence a genetic disease driven by gene mutations has been well established, yet its utilization in functional studies of cancer genes has not been fully explored. Here, we describe a simple genetics-based approach that can quickly and sensitively reveal the effe...

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Detalles Bibliográficos
Autores principales: Lei, Kefeng, Sun, Ran, Chen, Lee H., Diplas, Bill H., Moure, Casey J., Wang, Wenzhe, Hansen, Landon J., Tao, Yulei, Chen, Xufeng, Chen, Chin-Pu Jason, Greer, Paula K., Zhao, Fangping, Yan, Hai, Bigner, Darell D., Huang, Jiaoti, He, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104024/
https://www.ncbi.nlm.nih.gov/pubmed/30131529
http://dx.doi.org/10.1038/s41598-018-30062-z

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