Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we have gathered depth-controlled indentation viscoel...

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Autores principales: Antonovaite, Nelda, Beekmans, Steven V., Hol, Elly M., Wadman, Wytse J., Iannuzzi, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104037/
https://www.ncbi.nlm.nih.gov/pubmed/30131608
http://dx.doi.org/10.1038/s41598-018-31035-y
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author Antonovaite, Nelda
Beekmans, Steven V.
Hol, Elly M.
Wadman, Wytse J.
Iannuzzi, Davide
author_facet Antonovaite, Nelda
Beekmans, Steven V.
Hol, Elly M.
Wadman, Wytse J.
Iannuzzi, Davide
author_sort Antonovaite, Nelda
collection PubMed
description The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we have gathered depth-controlled indentation viscoelasticity maps of the hippocampus of acute horizontal live mouse brain slices. Our results confirm the highly viscoelestic nature of brain tissue. We further show that the mechanical properties are non-uniform and at least related to differences in morphological composition. Interestingly, areas with higher nuclear density appear to be softer than areas with lower nuclear density.
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spelling pubmed-61040372018-08-27 Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping Antonovaite, Nelda Beekmans, Steven V. Hol, Elly M. Wadman, Wytse J. Iannuzzi, Davide Sci Rep Article The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we have gathered depth-controlled indentation viscoelasticity maps of the hippocampus of acute horizontal live mouse brain slices. Our results confirm the highly viscoelestic nature of brain tissue. We further show that the mechanical properties are non-uniform and at least related to differences in morphological composition. Interestingly, areas with higher nuclear density appear to be softer than areas with lower nuclear density. Nature Publishing Group UK 2018-08-21 /pmc/articles/PMC6104037/ /pubmed/30131608 http://dx.doi.org/10.1038/s41598-018-31035-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Antonovaite, Nelda
Beekmans, Steven V.
Hol, Elly M.
Wadman, Wytse J.
Iannuzzi, Davide
Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
title Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
title_full Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
title_fullStr Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
title_full_unstemmed Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
title_short Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
title_sort regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104037/
https://www.ncbi.nlm.nih.gov/pubmed/30131608
http://dx.doi.org/10.1038/s41598-018-31035-y
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