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The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I–III colorectal cancer: a population‐based cohort study (C‐SCANS)

BACKGROUND: Muscle abnormalities such as low muscle mass and low muscle radiodensity are well known risk factors for unfavourable cancer prognosis. However, little is known in regard to the degree and impact of longitudinal changes in muscle mass and radiodensity within the context of cancer. Here,...

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Autores principales: Brown, Justin C., Caan, Bette J., Meyerhardt, Jeffrey A., Weltzien, Erin, Xiao, Jingjie, Cespedes Feliciano, Elizabeth M., Kroenke, Candyce H., Castillo, Adrienne, Kwan, Marilyn L., Prado, Carla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104108/
https://www.ncbi.nlm.nih.gov/pubmed/29766660
http://dx.doi.org/10.1002/jcsm.12305
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author Brown, Justin C.
Caan, Bette J.
Meyerhardt, Jeffrey A.
Weltzien, Erin
Xiao, Jingjie
Cespedes Feliciano, Elizabeth M.
Kroenke, Candyce H.
Castillo, Adrienne
Kwan, Marilyn L.
Prado, Carla M.
author_facet Brown, Justin C.
Caan, Bette J.
Meyerhardt, Jeffrey A.
Weltzien, Erin
Xiao, Jingjie
Cespedes Feliciano, Elizabeth M.
Kroenke, Candyce H.
Castillo, Adrienne
Kwan, Marilyn L.
Prado, Carla M.
author_sort Brown, Justin C.
collection PubMed
description BACKGROUND: Muscle abnormalities such as low muscle mass and low muscle radiodensity are well known risk factors for unfavourable cancer prognosis. However, little is known in regard to the degree and impact of longitudinal changes in muscle mass and radiodensity within the context of cancer. Here, we explore the relationship between muscle wasting and mortality in a large population‐based study of patients with non‐metastatic colorectal cancer (CRC). METHODS: A total of 1924 patients with stage I–III CRC who underwent surgical resection in the Kaiser Permanente Northern California Health System were included. Muscle mass and radiodensity were quantified using computed tomography images obtained at diagnosis and after approximately 14 months. Cox proportional‐hazards models were used to estimate hazard ratios for all‐cause mortality. RESULTS: The hazard ratio for all‐cause mortality among patients with the largest deterioration in muscle mass (≥2 SD; ≥11.4% loss from baseline), as compared with those who remained stable (±1 SD; 0.0 ± 5.7%) was 2.15 [95% confidence interval (CI): 1.59–2.92; P < 0.001]. The hazard ratio for all‐cause mortality among patients who experienced the largest deterioration in muscle radiodensity (≥2 SD; ≥20.2% loss from baseline), as compared with those who remained stable (±1 SD; 0.0 ± 10.1%) was 1.61 (95% CI: 1.20–2.15; P = 0.002). CONCLUSIONS: In patients with stage I–III CRC, muscle wasting is a risk factor for mortality, independent of change in body mass and other body composition parameters.
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spelling pubmed-61041082018-08-27 The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I–III colorectal cancer: a population‐based cohort study (C‐SCANS) Brown, Justin C. Caan, Bette J. Meyerhardt, Jeffrey A. Weltzien, Erin Xiao, Jingjie Cespedes Feliciano, Elizabeth M. Kroenke, Candyce H. Castillo, Adrienne Kwan, Marilyn L. Prado, Carla M. J Cachexia Sarcopenia Muscle Original Articles BACKGROUND: Muscle abnormalities such as low muscle mass and low muscle radiodensity are well known risk factors for unfavourable cancer prognosis. However, little is known in regard to the degree and impact of longitudinal changes in muscle mass and radiodensity within the context of cancer. Here, we explore the relationship between muscle wasting and mortality in a large population‐based study of patients with non‐metastatic colorectal cancer (CRC). METHODS: A total of 1924 patients with stage I–III CRC who underwent surgical resection in the Kaiser Permanente Northern California Health System were included. Muscle mass and radiodensity were quantified using computed tomography images obtained at diagnosis and after approximately 14 months. Cox proportional‐hazards models were used to estimate hazard ratios for all‐cause mortality. RESULTS: The hazard ratio for all‐cause mortality among patients with the largest deterioration in muscle mass (≥2 SD; ≥11.4% loss from baseline), as compared with those who remained stable (±1 SD; 0.0 ± 5.7%) was 2.15 [95% confidence interval (CI): 1.59–2.92; P < 0.001]. The hazard ratio for all‐cause mortality among patients who experienced the largest deterioration in muscle radiodensity (≥2 SD; ≥20.2% loss from baseline), as compared with those who remained stable (±1 SD; 0.0 ± 10.1%) was 1.61 (95% CI: 1.20–2.15; P = 0.002). CONCLUSIONS: In patients with stage I–III CRC, muscle wasting is a risk factor for mortality, independent of change in body mass and other body composition parameters. John Wiley and Sons Inc. 2018-05-15 2018-08 /pmc/articles/PMC6104108/ /pubmed/29766660 http://dx.doi.org/10.1002/jcsm.12305 Text en © 2018 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Brown, Justin C.
Caan, Bette J.
Meyerhardt, Jeffrey A.
Weltzien, Erin
Xiao, Jingjie
Cespedes Feliciano, Elizabeth M.
Kroenke, Candyce H.
Castillo, Adrienne
Kwan, Marilyn L.
Prado, Carla M.
The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I–III colorectal cancer: a population‐based cohort study (C‐SCANS)
title The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I–III colorectal cancer: a population‐based cohort study (C‐SCANS)
title_full The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I–III colorectal cancer: a population‐based cohort study (C‐SCANS)
title_fullStr The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I–III colorectal cancer: a population‐based cohort study (C‐SCANS)
title_full_unstemmed The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I–III colorectal cancer: a population‐based cohort study (C‐SCANS)
title_short The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I–III colorectal cancer: a population‐based cohort study (C‐SCANS)
title_sort deterioration of muscle mass and radiodensity is prognostic of poor survival in stage i–iii colorectal cancer: a population‐based cohort study (c‐scans)
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104108/
https://www.ncbi.nlm.nih.gov/pubmed/29766660
http://dx.doi.org/10.1002/jcsm.12305
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