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Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival

OBJECTIVE: The purpose of this article is to investigate the relationship between the plasma concentration of aldosterone and changes in the number of retinal ganglion cells (RGCs) after systemic administration of aldosterone. METHODS: An osmotic minipump that was subcutaneously implanted into the m...

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Autores principales: Takasago, Yukari, Hirooka, Kazuyuki, Nakano, Yuki, Kobayashi, Mamoru, Ono, Aoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104211/
https://www.ncbi.nlm.nih.gov/pubmed/30129805
http://dx.doi.org/10.1177/1470320318795001
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author Takasago, Yukari
Hirooka, Kazuyuki
Nakano, Yuki
Kobayashi, Mamoru
Ono, Aoi
author_facet Takasago, Yukari
Hirooka, Kazuyuki
Nakano, Yuki
Kobayashi, Mamoru
Ono, Aoi
author_sort Takasago, Yukari
collection PubMed
description OBJECTIVE: The purpose of this article is to investigate the relationship between the plasma concentration of aldosterone and changes in the number of retinal ganglion cells (RGCs) after systemic administration of aldosterone. METHODS: An osmotic minipump that was subcutaneously implanted into the midscapular region of rats administered 40, 80 or 160 μg/kg/day aldosterone or vehicle. Enzyme immunoassay kits were used to measure the plasma aldosterone concentrations two weeks after the systemic administration of aldosterone or vehicle. Six weeks after these systemic administrations, the number of RGCs was measured. RESULTS: The plasma aldosterone concentrations at two weeks after systemic administration of vehicle or 160 μg/kg/day aldosterone were 238 ± 17 pg/ml and 1750 ± 151 pg/ml (748.5% ± 183.2%), respectively. There was a significant decrease in the number of RGCs in the central retina of the rats after the administration of either 80 or 160 μg/kg/day aldosterone. In the peripheral retina, however, there was a significant decrease in the number of RGCs in 40, 80 or 160 μg/kg/day aldosterone. There was a significant correlation between the number of RGCs and plasma aldosterone concentration. CONCLUSIONS: After systemic administration of aldosterone, there was a negative correlation between the plasma aldosterone concentration and the number of RGCs.
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spelling pubmed-61042112018-08-27 Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival Takasago, Yukari Hirooka, Kazuyuki Nakano, Yuki Kobayashi, Mamoru Ono, Aoi J Renin Angiotensin Aldosterone Syst Original Article OBJECTIVE: The purpose of this article is to investigate the relationship between the plasma concentration of aldosterone and changes in the number of retinal ganglion cells (RGCs) after systemic administration of aldosterone. METHODS: An osmotic minipump that was subcutaneously implanted into the midscapular region of rats administered 40, 80 or 160 μg/kg/day aldosterone or vehicle. Enzyme immunoassay kits were used to measure the plasma aldosterone concentrations two weeks after the systemic administration of aldosterone or vehicle. Six weeks after these systemic administrations, the number of RGCs was measured. RESULTS: The plasma aldosterone concentrations at two weeks after systemic administration of vehicle or 160 μg/kg/day aldosterone were 238 ± 17 pg/ml and 1750 ± 151 pg/ml (748.5% ± 183.2%), respectively. There was a significant decrease in the number of RGCs in the central retina of the rats after the administration of either 80 or 160 μg/kg/day aldosterone. In the peripheral retina, however, there was a significant decrease in the number of RGCs in 40, 80 or 160 μg/kg/day aldosterone. There was a significant correlation between the number of RGCs and plasma aldosterone concentration. CONCLUSIONS: After systemic administration of aldosterone, there was a negative correlation between the plasma aldosterone concentration and the number of RGCs. SAGE Publications 2018-08-21 /pmc/articles/PMC6104211/ /pubmed/30129805 http://dx.doi.org/10.1177/1470320318795001 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Takasago, Yukari
Hirooka, Kazuyuki
Nakano, Yuki
Kobayashi, Mamoru
Ono, Aoi
Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival
title Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival
title_full Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival
title_fullStr Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival
title_full_unstemmed Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival
title_short Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival
title_sort elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104211/
https://www.ncbi.nlm.nih.gov/pubmed/30129805
http://dx.doi.org/10.1177/1470320318795001
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