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Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in Mice (Yonezawa Effect)
The existence of radiation-induced adaptive response (AR) was reported in varied biosystems. In mice, the first in vivo AR model was established using X-rays as both the priming and the challenge doses and rescue of bone marrow death as the end point. The underlying mechanism was due to the priming...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104214/ https://www.ncbi.nlm.nih.gov/pubmed/30150909 http://dx.doi.org/10.1177/1559325818790152 |
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author | Wang, Bing Tanaka, Kaoru Ninomiya, Yasuharu Maruyama, Kouichi Varès, Guillaume Katsube, Takanori Murakami, Masahiro Liu, Cuihua Fujimori, Akira Fujita, Kazuko Liu, Qiang Eguchi-Kasai, Kiyomi Nenoi, Mitsuru |
author_facet | Wang, Bing Tanaka, Kaoru Ninomiya, Yasuharu Maruyama, Kouichi Varès, Guillaume Katsube, Takanori Murakami, Masahiro Liu, Cuihua Fujimori, Akira Fujita, Kazuko Liu, Qiang Eguchi-Kasai, Kiyomi Nenoi, Mitsuru |
author_sort | Wang, Bing |
collection | PubMed |
description | The existence of radiation-induced adaptive response (AR) was reported in varied biosystems. In mice, the first in vivo AR model was established using X-rays as both the priming and the challenge doses and rescue of bone marrow death as the end point. The underlying mechanism was due to the priming radiation-induced resistance in the blood-forming tissues. In a series of investigations, we further demonstrated the existence of AR using different types of ionizing radiation (IR) including low linear energy transfer (LET) X-rays and high LET heavy ion. In this article, we validated hematopoietic stem cells/hematopoietic progenitor cells (HSCs/HPCs) measured as endogenous colony-forming units-spleen (CFU-S) under AR inducible and uninducible conditions using combination of different types of IR. We confirmed the consistency of increased CFU-S number change with the AR inducible condition. These findings suggest that AR in mice induced by different types of IR would share at least in part a common underlying mechanism, the priming IR-induced resistance in the blood-forming tissues, which would lead to a protective effect on the HSCs/HPCs and play an important role in rescuing the animals from bone marrow death. These findings provide a new insight into the mechanistic study on AR in vivo. |
format | Online Article Text |
id | pubmed-6104214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-61042142018-08-27 Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in Mice (Yonezawa Effect) Wang, Bing Tanaka, Kaoru Ninomiya, Yasuharu Maruyama, Kouichi Varès, Guillaume Katsube, Takanori Murakami, Masahiro Liu, Cuihua Fujimori, Akira Fujita, Kazuko Liu, Qiang Eguchi-Kasai, Kiyomi Nenoi, Mitsuru Dose Response Potential Clinical Implication of LDR Hormesis and Adaptive Response The existence of radiation-induced adaptive response (AR) was reported in varied biosystems. In mice, the first in vivo AR model was established using X-rays as both the priming and the challenge doses and rescue of bone marrow death as the end point. The underlying mechanism was due to the priming radiation-induced resistance in the blood-forming tissues. In a series of investigations, we further demonstrated the existence of AR using different types of ionizing radiation (IR) including low linear energy transfer (LET) X-rays and high LET heavy ion. In this article, we validated hematopoietic stem cells/hematopoietic progenitor cells (HSCs/HPCs) measured as endogenous colony-forming units-spleen (CFU-S) under AR inducible and uninducible conditions using combination of different types of IR. We confirmed the consistency of increased CFU-S number change with the AR inducible condition. These findings suggest that AR in mice induced by different types of IR would share at least in part a common underlying mechanism, the priming IR-induced resistance in the blood-forming tissues, which would lead to a protective effect on the HSCs/HPCs and play an important role in rescuing the animals from bone marrow death. These findings provide a new insight into the mechanistic study on AR in vivo. SAGE Publications 2018-08-20 /pmc/articles/PMC6104214/ /pubmed/30150909 http://dx.doi.org/10.1177/1559325818790152 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Potential Clinical Implication of LDR Hormesis and Adaptive Response Wang, Bing Tanaka, Kaoru Ninomiya, Yasuharu Maruyama, Kouichi Varès, Guillaume Katsube, Takanori Murakami, Masahiro Liu, Cuihua Fujimori, Akira Fujita, Kazuko Liu, Qiang Eguchi-Kasai, Kiyomi Nenoi, Mitsuru Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in Mice (Yonezawa Effect) |
title | Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells
Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in
Mice (Yonezawa Effect) |
title_full | Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells
Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in
Mice (Yonezawa Effect) |
title_fullStr | Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells
Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in
Mice (Yonezawa Effect) |
title_full_unstemmed | Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells
Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in
Mice (Yonezawa Effect) |
title_short | Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells
Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in
Mice (Yonezawa Effect) |
title_sort | increased hematopoietic stem cells/hematopoietic progenitor cells
measured as endogenous spleen colonies in radiation-induced adaptive response in
mice (yonezawa effect) |
topic | Potential Clinical Implication of LDR Hormesis and Adaptive Response |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104214/ https://www.ncbi.nlm.nih.gov/pubmed/30150909 http://dx.doi.org/10.1177/1559325818790152 |
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