Targeted Reactivation of FMR1 Transcription in Fragile X Syndrome Embryonic Stem Cells

Fragile X Syndrome (FXS) is the most common inherited cause of intellectual disability and autism. It results from expansion of a CGG nucleotide repeat in the 5′ untranslated region (UTR) of FMR1. Large expansions elicit repeat and promoter hyper-methylation, heterochromatin formation, FMR1 transcri...

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Detalles Bibliográficos
Autores principales: Haenfler, Jill M., Skariah, Geena, Rodriguez, Caitlin M., Monteiro da Rocha, Andre, Parent, Jack M., Smith, Gary D., Todd, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104480/
https://www.ncbi.nlm.nih.gov/pubmed/30158855
http://dx.doi.org/10.3389/fnmol.2018.00282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104480/
https://www.ncbi.nlm.nih.gov/pubmed/30158855
http://dx.doi.org/10.3389/fnmol.2018.00282

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