Successful treatment of C. auris shunt infection with intraventricular caspofungin

C. auris is an emerging fungal pathogen with high prevalence of resistance to current antifungal agents. Central nervous system infection with C. auris has been infrequently described. We describe here an adult with nosocomial CSF shunt infection due to multi drug resistant C. auris. Systemic therap...

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Detalles Bibliográficos
Autores principales: Singhal, Tanu, Kumar, Abhaya, Borade, Prashant, Shah, Sweta, Soman, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104577/
https://www.ncbi.nlm.nih.gov/pubmed/30140604
http://dx.doi.org/10.1016/j.mmcr.2018.08.005
Descripción
Sumario:C. auris is an emerging fungal pathogen with high prevalence of resistance to current antifungal agents. Central nervous system infection with C. auris has been infrequently described. We describe here an adult with nosocomial CSF shunt infection due to multi drug resistant C. auris. Systemic therapy with echinocandin and flucytosine failed. Fortunately, administration of daily intraventricular caspofungin 10 mg for 10 days in conjunction with systemic voriconazole resulted in both clinical and microbiological cure.

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