Successful treatment of C. auris shunt infection with intraventricular caspofungin

C. auris is an emerging fungal pathogen with high prevalence of resistance to current antifungal agents. Central nervous system infection with C. auris has been infrequently described. We describe here an adult with nosocomial CSF shunt infection due to multi drug resistant C. auris. Systemic therap...

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Detalles Bibliográficos
Autores principales: Singhal, Tanu, Kumar, Abhaya, Borade, Prashant, Shah, Sweta, Soman, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104577/
https://www.ncbi.nlm.nih.gov/pubmed/30140604
http://dx.doi.org/10.1016/j.mmcr.2018.08.005
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author Singhal, Tanu
Kumar, Abhaya
Borade, Prashant
Shah, Sweta
Soman, Rajeev
author_facet Singhal, Tanu
Kumar, Abhaya
Borade, Prashant
Shah, Sweta
Soman, Rajeev
author_sort Singhal, Tanu
collection PubMed
description C. auris is an emerging fungal pathogen with high prevalence of resistance to current antifungal agents. Central nervous system infection with C. auris has been infrequently described. We describe here an adult with nosocomial CSF shunt infection due to multi drug resistant C. auris. Systemic therapy with echinocandin and flucytosine failed. Fortunately, administration of daily intraventricular caspofungin 10 mg for 10 days in conjunction with systemic voriconazole resulted in both clinical and microbiological cure.
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spelling pubmed-61045772018-08-23 Successful treatment of C. auris shunt infection with intraventricular caspofungin Singhal, Tanu Kumar, Abhaya Borade, Prashant Shah, Sweta Soman, Rajeev Med Mycol Case Rep Case Report C. auris is an emerging fungal pathogen with high prevalence of resistance to current antifungal agents. Central nervous system infection with C. auris has been infrequently described. We describe here an adult with nosocomial CSF shunt infection due to multi drug resistant C. auris. Systemic therapy with echinocandin and flucytosine failed. Fortunately, administration of daily intraventricular caspofungin 10 mg for 10 days in conjunction with systemic voriconazole resulted in both clinical and microbiological cure. Elsevier 2018-08-11 /pmc/articles/PMC6104577/ /pubmed/30140604 http://dx.doi.org/10.1016/j.mmcr.2018.08.005 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Singhal, Tanu
Kumar, Abhaya
Borade, Prashant
Shah, Sweta
Soman, Rajeev
Successful treatment of C. auris shunt infection with intraventricular caspofungin
title Successful treatment of C. auris shunt infection with intraventricular caspofungin
title_full Successful treatment of C. auris shunt infection with intraventricular caspofungin
title_fullStr Successful treatment of C. auris shunt infection with intraventricular caspofungin
title_full_unstemmed Successful treatment of C. auris shunt infection with intraventricular caspofungin
title_short Successful treatment of C. auris shunt infection with intraventricular caspofungin
title_sort successful treatment of c. auris shunt infection with intraventricular caspofungin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104577/
https://www.ncbi.nlm.nih.gov/pubmed/30140604
http://dx.doi.org/10.1016/j.mmcr.2018.08.005
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