RNA polymerase I activation and hibernation: unique mechanisms for unique genes

In yeast, transcription of ribosomal DNA (rDNA) by RNA polymerase I (Pol I) is regulated by unique mechanisms acting at the level of the enzyme. Under stress situations such as starvation, Pol I hibernates through dimerization. When growth conditions are restored, dimer disassembly and Rrn3 binding...

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Detalles Bibliográficos
Autor principal: Fernández-Tornero, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104688/
https://www.ncbi.nlm.nih.gov/pubmed/29372670
http://dx.doi.org/10.1080/21541264.2017.1416267
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author Fernández-Tornero, Carlos
author_facet Fernández-Tornero, Carlos
author_sort Fernández-Tornero, Carlos
collection PubMed
description In yeast, transcription of ribosomal DNA (rDNA) by RNA polymerase I (Pol I) is regulated by unique mechanisms acting at the level of the enzyme. Under stress situations such as starvation, Pol I hibernates through dimerization. When growth conditions are restored, dimer disassembly and Rrn3 binding drive enzyme activation and subsequent recruitment to rDNA.
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spelling pubmed-61046882018-08-27 RNA polymerase I activation and hibernation: unique mechanisms for unique genes Fernández-Tornero, Carlos Transcription Point-of-View In yeast, transcription of ribosomal DNA (rDNA) by RNA polymerase I (Pol I) is regulated by unique mechanisms acting at the level of the enzyme. Under stress situations such as starvation, Pol I hibernates through dimerization. When growth conditions are restored, dimer disassembly and Rrn3 binding drive enzyme activation and subsequent recruitment to rDNA. Taylor & Francis 2018-01-26 /pmc/articles/PMC6104688/ /pubmed/29372670 http://dx.doi.org/10.1080/21541264.2017.1416267 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Point-of-View
Fernández-Tornero, Carlos
RNA polymerase I activation and hibernation: unique mechanisms for unique genes
title RNA polymerase I activation and hibernation: unique mechanisms for unique genes
title_full RNA polymerase I activation and hibernation: unique mechanisms for unique genes
title_fullStr RNA polymerase I activation and hibernation: unique mechanisms for unique genes
title_full_unstemmed RNA polymerase I activation and hibernation: unique mechanisms for unique genes
title_short RNA polymerase I activation and hibernation: unique mechanisms for unique genes
title_sort rna polymerase i activation and hibernation: unique mechanisms for unique genes
topic Point-of-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104688/
https://www.ncbi.nlm.nih.gov/pubmed/29372670
http://dx.doi.org/10.1080/21541264.2017.1416267
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