Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation

While structures of the RNA polymerase (Pol) II initiation complex have been resolved and extensively studied, the Pol I initiation complex remained elusive. Here, we review the recent structural analyses of the yeast Pol I transcription initiation complex that reveal several unique and unexpected P...

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Detalles Bibliográficos
Autores principales: Jackobel, Ashleigh J., Han, Yan, He, Yuan, Knutson, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104693/
https://www.ncbi.nlm.nih.gov/pubmed/29264963
http://dx.doi.org/10.1080/21541264.2017.1416268
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author Jackobel, Ashleigh J.
Han, Yan
He, Yuan
Knutson, Bruce A.
author_facet Jackobel, Ashleigh J.
Han, Yan
He, Yuan
Knutson, Bruce A.
author_sort Jackobel, Ashleigh J.
collection PubMed
description While structures of the RNA polymerase (Pol) II initiation complex have been resolved and extensively studied, the Pol I initiation complex remained elusive. Here, we review the recent structural analyses of the yeast Pol I transcription initiation complex that reveal several unique and unexpected Pol I-specific properties.
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spelling pubmed-61046932018-08-27 Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation Jackobel, Ashleigh J. Han, Yan He, Yuan Knutson, Bruce A. Transcription Point-of-View While structures of the RNA polymerase (Pol) II initiation complex have been resolved and extensively studied, the Pol I initiation complex remained elusive. Here, we review the recent structural analyses of the yeast Pol I transcription initiation complex that reveal several unique and unexpected Pol I-specific properties. Taylor & Francis 2018-01-15 /pmc/articles/PMC6104693/ /pubmed/29264963 http://dx.doi.org/10.1080/21541264.2017.1416268 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Point-of-View
Jackobel, Ashleigh J.
Han, Yan
He, Yuan
Knutson, Bruce A.
Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation
title Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation
title_full Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation
title_fullStr Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation
title_full_unstemmed Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation
title_short Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation
title_sort breaking the mold: structures of the rna polymerase i transcription complex reveal a new path for initiation
topic Point-of-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104693/
https://www.ncbi.nlm.nih.gov/pubmed/29264963
http://dx.doi.org/10.1080/21541264.2017.1416268
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