Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein

Ebolaviruses cause severe disease in humans, and identification of monoclonal antibodies (mAbs) that are effective against multiple ebolaviruses are important for therapeutics development. Here we describe a distinct class of broadly neutralizing human mAbs with protective capacity against three ebo...

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Detalles Bibliográficos
Autores principales: Gilchuk, Pavlo, Kuzmina, Natalia, Ilinykh, Philipp A., Huang, Kai, Gunn, Bronwyn M., Bryan, Aubrey, Davidson, Edgar, Doranz, Benjamin J., Turner, Hannah L., Fusco, Marnie L., Bramble, Matthew S., Hoff, Nicole A., Binshtein, Elad, Kose, Nurgun, Flyak, Andrew I., Flinko, Robin, Orlandi, Chiara, Carnahan, Robert, Parrish, Erica H., Sevy, Alexander M., Bombardi, Robin G., Singh, Prashant K., Mukadi, Patrick, Muyembe-Tamfum, Jean Jacques, Ohi, Melanie D., Saphire, Erica Ollmann, Lewis, George K., Alter, Galit, Ward, Andrew B., Rimoin, Anne W., Bukreyev, Alexander, Crowe, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104738/
https://www.ncbi.nlm.nih.gov/pubmed/30029854
http://dx.doi.org/10.1016/j.immuni.2018.06.018

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