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DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions

HIV-1 Envelope (Env) mediates viral-host membrane fusion after binding host-receptor CD4 and coreceptor. Soluble envelopes (SOSIPs), designed to mimic prefusion conformational states of virion-bound envelopes, are proposed immunogens for eliciting neutralizing antibodies, yet only static structures...

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Detalles Bibliográficos
Autores principales:	Stadtmueller, Beth M., Bridges, Michael D., Dam, Kim-Marie, Lerch, Michael T., Huey-Tubman, Kathryn E., Hubbell, Wayne L., Bjorkman, Pamela J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104740/ https://www.ncbi.nlm.nih.gov/pubmed/30076100 http://dx.doi.org/10.1016/j.immuni.2018.06.017

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