Phase I trial of pod-intravaginal rings delivering antiretroviral agents for HIV-1 prevention: Rectal drug exposure from vaginal dosing with tenofovir disoproxil fumarate, emtricitabine, and maraviroc

BACKGROUND: Intravaginal rings (IVRs) can deliver antiretroviral (ARV) agents for HIV pre-exposure prophylaxis (PrEP), theoretically overcoming adherence concerns associated with frequent dosing. However, topical vaginal ARV drug delivery has not simultaneously led to sufficient rectal drug exposure...

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Detalles Bibliográficos
Autores principales: Vincent, Kathleen Listiak, Moss, John A., Marzinke, Mark A., Hendrix, Craig W., Anton, Peter A., Gunawardana, Manjula, Dawson, Lauren N., Olive, Trevelyn J., Pyles, Richard B., Baum, Marc M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104940/
https://www.ncbi.nlm.nih.gov/pubmed/30133534
http://dx.doi.org/10.1371/journal.pone.0201952

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