ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile

CD47 is a widely expressed cell surface protein that functions as an immune checkpoint in cancer. When expressed by tumor cells, CD47 can bind SIRPα on myeloid cells, leading to suppression of tumor cell phagocytosis and other innate immune functions. CD47-SIRPα signaling has also been implicated in...

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Detalles Bibliográficos
Autores principales: Kauder, Steven E., Kuo, Tracy C., Harrabi, Ons, Chen, Amy, Sangalang, Emma, Doyle, Laura, Rocha, Sony S., Bollini, Sangeetha, Han, Bora, Sim, Janet, Pons, Jaume, Wan, Hong I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104973/
https://www.ncbi.nlm.nih.gov/pubmed/30133535
http://dx.doi.org/10.1371/journal.pone.0201832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104973/
https://www.ncbi.nlm.nih.gov/pubmed/30133535
http://dx.doi.org/10.1371/journal.pone.0201832

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