Using Dog Scent Detection as a Point-of-Care Tool to Identify Toxigenic Clostridium difficile in Stool

We evaluated the operating characteristics of 2 comparably trained dogs as a “point-of-care” diagnostic tool to detect toxin gene-positive Clostridium difficile. Although each dog could detect toxin gene-positive C difficile in stool specimens with sensitivities of 77.6 and 92.6 and specificities of...

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Autores principales: Taylor, Maureen T, McCready, Janine, Broukhanski, George, Kirpalaney, Sakshi, Lutz, Haydon, Powis, Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105104/
https://www.ncbi.nlm.nih.gov/pubmed/30151408
http://dx.doi.org/10.1093/ofid/ofy179
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author Taylor, Maureen T
McCready, Janine
Broukhanski, George
Kirpalaney, Sakshi
Lutz, Haydon
Powis, Jeff
author_facet Taylor, Maureen T
McCready, Janine
Broukhanski, George
Kirpalaney, Sakshi
Lutz, Haydon
Powis, Jeff
author_sort Taylor, Maureen T
collection PubMed
description We evaluated the operating characteristics of 2 comparably trained dogs as a “point-of-care” diagnostic tool to detect toxin gene-positive Clostridium difficile. Although each dog could detect toxin gene-positive C difficile in stool specimens with sensitivities of 77.6 and 92.6 and specificities of 85.1 and 84.5, respectively, interrater reliability is only modest (Cohen’s kappa 0.52), limiting widespread application.
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spelling pubmed-61051042018-08-27 Using Dog Scent Detection as a Point-of-Care Tool to Identify Toxigenic Clostridium difficile in Stool Taylor, Maureen T McCready, Janine Broukhanski, George Kirpalaney, Sakshi Lutz, Haydon Powis, Jeff Open Forum Infect Dis Brief Report We evaluated the operating characteristics of 2 comparably trained dogs as a “point-of-care” diagnostic tool to detect toxin gene-positive Clostridium difficile. Although each dog could detect toxin gene-positive C difficile in stool specimens with sensitivities of 77.6 and 92.6 and specificities of 85.1 and 84.5, respectively, interrater reliability is only modest (Cohen’s kappa 0.52), limiting widespread application. Oxford University Press 2018-08-22 /pmc/articles/PMC6105104/ /pubmed/30151408 http://dx.doi.org/10.1093/ofid/ofy179 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Taylor, Maureen T
McCready, Janine
Broukhanski, George
Kirpalaney, Sakshi
Lutz, Haydon
Powis, Jeff
Using Dog Scent Detection as a Point-of-Care Tool to Identify Toxigenic Clostridium difficile in Stool
title Using Dog Scent Detection as a Point-of-Care Tool to Identify Toxigenic Clostridium difficile in Stool
title_full Using Dog Scent Detection as a Point-of-Care Tool to Identify Toxigenic Clostridium difficile in Stool
title_fullStr Using Dog Scent Detection as a Point-of-Care Tool to Identify Toxigenic Clostridium difficile in Stool
title_full_unstemmed Using Dog Scent Detection as a Point-of-Care Tool to Identify Toxigenic Clostridium difficile in Stool
title_short Using Dog Scent Detection as a Point-of-Care Tool to Identify Toxigenic Clostridium difficile in Stool
title_sort using dog scent detection as a point-of-care tool to identify toxigenic clostridium difficile in stool
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105104/
https://www.ncbi.nlm.nih.gov/pubmed/30151408
http://dx.doi.org/10.1093/ofid/ofy179
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