PLD3 and PLD4 are single stranded acid exonucleases that regulate endosomal nucleic acid sensing

Leukocyte sensing of microbial genetic material often elicits beneficial proinflammatory cytokines, but dysregulated responses can cause severe pathogenesis. Genome-wide association studies have linked Phospholipase D3 (PLD3) to Alzheimer’s disease and PLD4 to rheumatoid arthritis and systemic scler...

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Detalles Bibliográficos
Autores principales: Gavin, Amanda L., Huang, Deli, Huber, Christoph, Mårtensson, Annica, Tardif, Virginie, Skog, Patrick D., Blane, Tanya R., Thinnes, Therese C., Osborn, Kent, Chong, Hayley S., Kargaran, Farnaz, Kimm, Phoebe, Zeitjian, Armen, Sielski, Rachel L., Briggs, Megan, Schulz, Sebastian R., Zarpellon, Alessandro, Cravatt, Benjamin, Pang, Ee Shan, Teijaro, John, de la Torre, Juan Carlos, O’Keeffe, Meredith, Hochrein, Hubertus, Damme, Markus, Teyton, Luc, Lawson, Brian R., Nemazee, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105523/
https://www.ncbi.nlm.nih.gov/pubmed/30111894
http://dx.doi.org/10.1038/s41590-018-0179-y

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