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Depression is associated with enhanced aversive Pavlovian control over instrumental behaviour
The dynamic modulation of instrumental behaviour by conditioned Pavlovian cues is an important process in decision-making. Patients with major depressive disorder (MDD) are known to exhibit mood-congruent biases in information processing, which may occur due to Pavlovian influences, but this hypothe...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105578/ https://www.ncbi.nlm.nih.gov/pubmed/30135491 http://dx.doi.org/10.1038/s41598-018-30828-5 |
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author | Nord, C. L. Lawson, R. P. Huys, Q. J. M. Pilling, S. Roiser, J. P. |
author_facet | Nord, C. L. Lawson, R. P. Huys, Q. J. M. Pilling, S. Roiser, J. P. |
author_sort | Nord, C. L. |
collection | PubMed |
description | The dynamic modulation of instrumental behaviour by conditioned Pavlovian cues is an important process in decision-making. Patients with major depressive disorder (MDD) are known to exhibit mood-congruent biases in information processing, which may occur due to Pavlovian influences, but this hypothesis has never been tested directly in an unmedicated sample. To address this we tested unmedicated MDD patients and healthy volunteers on a computerized Pavlovian-Instrumental Transfer (PIT) task designed to separately examine instrumental approach and withdrawal actions in the context of Pavlovian appetitive and aversive cues. This design allowed us to directly measure the degree to which Pavlovian cues influence instrumental responding. Depressed patients were profoundly influenced by aversive Pavlovian stimuli, to a significantly greater degree than healthy volunteers. This was the case for instrumental behaviour both in the approach condition (in which aversive Pavlovian cues inhibited ‘go’ responses), and in the withdrawal condition (in which aversive Pavlovian cues facilitated ‘go’ responses). Exaggerated aversive PIT provides a potential cognitive mechanism for biased emotion processing in major depression. This finding also has wider significance for the understanding of disrupted motivational processing in neuropsychiatric disorders. |
format | Online Article Text |
id | pubmed-6105578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61055782018-08-27 Depression is associated with enhanced aversive Pavlovian control over instrumental behaviour Nord, C. L. Lawson, R. P. Huys, Q. J. M. Pilling, S. Roiser, J. P. Sci Rep Article The dynamic modulation of instrumental behaviour by conditioned Pavlovian cues is an important process in decision-making. Patients with major depressive disorder (MDD) are known to exhibit mood-congruent biases in information processing, which may occur due to Pavlovian influences, but this hypothesis has never been tested directly in an unmedicated sample. To address this we tested unmedicated MDD patients and healthy volunteers on a computerized Pavlovian-Instrumental Transfer (PIT) task designed to separately examine instrumental approach and withdrawal actions in the context of Pavlovian appetitive and aversive cues. This design allowed us to directly measure the degree to which Pavlovian cues influence instrumental responding. Depressed patients were profoundly influenced by aversive Pavlovian stimuli, to a significantly greater degree than healthy volunteers. This was the case for instrumental behaviour both in the approach condition (in which aversive Pavlovian cues inhibited ‘go’ responses), and in the withdrawal condition (in which aversive Pavlovian cues facilitated ‘go’ responses). Exaggerated aversive PIT provides a potential cognitive mechanism for biased emotion processing in major depression. This finding also has wider significance for the understanding of disrupted motivational processing in neuropsychiatric disorders. Nature Publishing Group UK 2018-08-22 /pmc/articles/PMC6105578/ /pubmed/30135491 http://dx.doi.org/10.1038/s41598-018-30828-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Nord, C. L. Lawson, R. P. Huys, Q. J. M. Pilling, S. Roiser, J. P. Depression is associated with enhanced aversive Pavlovian control over instrumental behaviour |
title | Depression is associated with enhanced aversive Pavlovian control over instrumental behaviour |
title_full | Depression is associated with enhanced aversive Pavlovian control over instrumental behaviour |
title_fullStr | Depression is associated with enhanced aversive Pavlovian control over instrumental behaviour |
title_full_unstemmed | Depression is associated with enhanced aversive Pavlovian control over instrumental behaviour |
title_short | Depression is associated with enhanced aversive Pavlovian control over instrumental behaviour |
title_sort | depression is associated with enhanced aversive pavlovian control over instrumental behaviour |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105578/ https://www.ncbi.nlm.nih.gov/pubmed/30135491 http://dx.doi.org/10.1038/s41598-018-30828-5 |
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