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Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis
Although patients with primary biliary cholangitis (PBC) experience a variety of symptoms that could impair health-related quality of life (HRQOL), no studies regarding symptoms and impact of PBC on HRQOL have been performed in Asian countries. Herein, we aimed to evaluate symptoms and HRQOL in Japa...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105590/ https://www.ncbi.nlm.nih.gov/pubmed/30135523 http://dx.doi.org/10.1038/s41598-018-31063-8 |
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author | Yagi, Minami Tanaka, Atsushi Abe, Masanori Namisaki, Tadashi Yoshiji, Hitoshi Takahashi, Atsushi Ohira, Hiromasa Komori, Atsumasa Yamagiwa, Satoshi Kikuchi, Kentaro Yasunaka, Tetsuya Takaki, Akinobu Ueno, Yoshiyuki Honda, Akira Matsuzaki, Yasushi Takikawa, Hajime |
author_facet | Yagi, Minami Tanaka, Atsushi Abe, Masanori Namisaki, Tadashi Yoshiji, Hitoshi Takahashi, Atsushi Ohira, Hiromasa Komori, Atsumasa Yamagiwa, Satoshi Kikuchi, Kentaro Yasunaka, Tetsuya Takaki, Akinobu Ueno, Yoshiyuki Honda, Akira Matsuzaki, Yasushi Takikawa, Hajime |
author_sort | Yagi, Minami |
collection | PubMed |
description | Although patients with primary biliary cholangitis (PBC) experience a variety of symptoms that could impair health-related quality of life (HRQOL), no studies regarding symptoms and impact of PBC on HRQOL have been performed in Asian countries. Herein, we aimed to evaluate symptoms and HRQOL in Japanese PBC patients. We performed a multicenter, observational, cross-sectional study. The PBC-40 and the short form (SF)-36 were used as measures of symptoms and HRQOL. Four-hundred-ninety-six patients with PBC were enrolled. In the PBC-40, the average score was highest in the emotional domain, followed by the fatigue domain. The HRQOL measured using SF-36 was also impaired, especially in the physical and role-social components. After adjustments of variables, female sex, younger age at diagnosis, and lower serum albumin level were independently associated with fatigue scores, while a longer follow-up period and lower serum albumin levels were associated with itch scores. |
format | Online Article Text |
id | pubmed-6105590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61055902018-08-27 Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis Yagi, Minami Tanaka, Atsushi Abe, Masanori Namisaki, Tadashi Yoshiji, Hitoshi Takahashi, Atsushi Ohira, Hiromasa Komori, Atsumasa Yamagiwa, Satoshi Kikuchi, Kentaro Yasunaka, Tetsuya Takaki, Akinobu Ueno, Yoshiyuki Honda, Akira Matsuzaki, Yasushi Takikawa, Hajime Sci Rep Article Although patients with primary biliary cholangitis (PBC) experience a variety of symptoms that could impair health-related quality of life (HRQOL), no studies regarding symptoms and impact of PBC on HRQOL have been performed in Asian countries. Herein, we aimed to evaluate symptoms and HRQOL in Japanese PBC patients. We performed a multicenter, observational, cross-sectional study. The PBC-40 and the short form (SF)-36 were used as measures of symptoms and HRQOL. Four-hundred-ninety-six patients with PBC were enrolled. In the PBC-40, the average score was highest in the emotional domain, followed by the fatigue domain. The HRQOL measured using SF-36 was also impaired, especially in the physical and role-social components. After adjustments of variables, female sex, younger age at diagnosis, and lower serum albumin level were independently associated with fatigue scores, while a longer follow-up period and lower serum albumin levels were associated with itch scores. Nature Publishing Group UK 2018-08-22 /pmc/articles/PMC6105590/ /pubmed/30135523 http://dx.doi.org/10.1038/s41598-018-31063-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yagi, Minami Tanaka, Atsushi Abe, Masanori Namisaki, Tadashi Yoshiji, Hitoshi Takahashi, Atsushi Ohira, Hiromasa Komori, Atsumasa Yamagiwa, Satoshi Kikuchi, Kentaro Yasunaka, Tetsuya Takaki, Akinobu Ueno, Yoshiyuki Honda, Akira Matsuzaki, Yasushi Takikawa, Hajime Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis |
title | Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis |
title_full | Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis |
title_fullStr | Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis |
title_full_unstemmed | Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis |
title_short | Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis |
title_sort | symptoms and health-related quality of life in japanese patients with primary biliary cholangitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105590/ https://www.ncbi.nlm.nih.gov/pubmed/30135523 http://dx.doi.org/10.1038/s41598-018-31063-8 |
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