Risk factors associated with extracranial atherosclerosis in old patients with acute ischemic stroke

The aim of this study was to identify risk factors associated with extracranial atherosclerosis (ECAS) in old Chinese patients with ischemic stroke. Eligible patients were divided into two groups: <60years group and ≥60 years group. The incidence, severity of ECAS and risk factors related to ECAS were compared between the two groups. In total, 921 patients were included in the analysis. The distribution of ECAS between the two age groups did not show difference (P = 0.747).But severe ECAS stenosis was more common in <60years group than in ≥60years group (x(2) = 8.307, P = 0.013). Compared with <60years group, factors contributed to higher risk of ECAS in ≥60year group were hypertension(OR = 6.279, P = 0.000), heart disease(OR = 5.618, P = 0.032) and atrial fibrillation(OR = 7.477, P = 0.015). However, though smoking was higher in the <60years group (x(2) = 7.664, P = 0.010) than in ≥60year group, multivariate analysis showed the difference was not significant(P = 0.879). Further studies should focus on risk factors in young ECAS patients. Different risk factors might contribute to ECAS in old age groups compared to young groups. Risk factor prevention/control measures should be strengthened in those with high risk of ECAS for decreasing stroke risk.