KRAS(G12D) and TP53(R167H) Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs

Although survival has improved in recent years, the prognosis of patients with advanced pancreatic ductal adenocarcinoma (PDAC) remains poor. Despite substantial differences in anatomy, physiology, genetics, and metabolism, the overwhelming majority of preclinical testing relies on transgenic mice....

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Detalles Bibliográficos
Autores principales: Principe, Daniel R., Overgaard, Nana Haahr, Park, Alex J., Diaz, Andrew M., Torres, Carolina, McKinney, Ronald, Dorman, Matthew J., Castellanos, Karla, Schwind, Regina, Dawson, David W., Rana, Ajay, Maker, Ajay, Munshi, Hidayatullah G., Rund, Lauretta A., Grippo, Paul J., Schook, Lawrence B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105629/
https://www.ncbi.nlm.nih.gov/pubmed/30135483
http://dx.doi.org/10.1038/s41598-018-30916-6

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