Cargando…
HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
It is definitively established that mutations in transcription factor HIF-2α are causative of both neuroendocrine tumors (class 1 disease) and polycythemia (class 2 disease). However, the molecular mechanism that underlies this emergent genotype–phenotype relationship has remained unclear. Here, we...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105673/ https://www.ncbi.nlm.nih.gov/pubmed/30135421 http://dx.doi.org/10.1038/s41467-018-05554-1 |