Isolation and characterization of novel bat paramyxovirus B16-40 potentially belonging to the proposed genus Shaanvirus

The bat paramyxovirus B16-40 was first isolated in Korea in this study. Using the isolated virus, we could obtain not only genomic information, but also several biological characteristics of the virus. In the phylogenetic analysis, the virus was found to belong to the recently proposed genus Shaanvi...

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Autores principales: Noh, Ji Yeong, Jeong, Dae Gwin, Yoon, Sun-Woo, Kim, Ji Hyung, Choi, Yong Gun, Kang, Shien-Young, Kim, Hye Kwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105681/
https://www.ncbi.nlm.nih.gov/pubmed/30135435
http://dx.doi.org/10.1038/s41598-018-30319-7
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author Noh, Ji Yeong
Jeong, Dae Gwin
Yoon, Sun-Woo
Kim, Ji Hyung
Choi, Yong Gun
Kang, Shien-Young
Kim, Hye Kwon
author_facet Noh, Ji Yeong
Jeong, Dae Gwin
Yoon, Sun-Woo
Kim, Ji Hyung
Choi, Yong Gun
Kang, Shien-Young
Kim, Hye Kwon
author_sort Noh, Ji Yeong
collection PubMed
description The bat paramyxovirus B16-40 was first isolated in Korea in this study. Using the isolated virus, we could obtain not only genomic information, but also several biological characteristics of the virus. In the phylogenetic analysis, the virus was found to belong to the recently proposed genus Shaanvirus. Through sequence analyses and in vitro testing, the isolated virus was also found to have haemagglutinin-neuraminidase (HN) protein as one of the structural proteins. When mouse antiserum was generated against the isolated virus and tested, it was cross-reactive to human parainfluenza virus 1 in an indirect immunofluorescence assay but could not cross-neutralize human parainfluenza virus 1. In addition, the bat paramyxovirus B16-40 was not infectious in the mouse model. Collectively, this study provided basic information on further classification of the bat paramyxovirus B16-40 and related viruses in the proposed genus Shaanvirus.
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spelling pubmed-61056812018-08-28 Isolation and characterization of novel bat paramyxovirus B16-40 potentially belonging to the proposed genus Shaanvirus Noh, Ji Yeong Jeong, Dae Gwin Yoon, Sun-Woo Kim, Ji Hyung Choi, Yong Gun Kang, Shien-Young Kim, Hye Kwon Sci Rep Article The bat paramyxovirus B16-40 was first isolated in Korea in this study. Using the isolated virus, we could obtain not only genomic information, but also several biological characteristics of the virus. In the phylogenetic analysis, the virus was found to belong to the recently proposed genus Shaanvirus. Through sequence analyses and in vitro testing, the isolated virus was also found to have haemagglutinin-neuraminidase (HN) protein as one of the structural proteins. When mouse antiserum was generated against the isolated virus and tested, it was cross-reactive to human parainfluenza virus 1 in an indirect immunofluorescence assay but could not cross-neutralize human parainfluenza virus 1. In addition, the bat paramyxovirus B16-40 was not infectious in the mouse model. Collectively, this study provided basic information on further classification of the bat paramyxovirus B16-40 and related viruses in the proposed genus Shaanvirus. Nature Publishing Group UK 2018-08-22 /pmc/articles/PMC6105681/ /pubmed/30135435 http://dx.doi.org/10.1038/s41598-018-30319-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Noh, Ji Yeong
Jeong, Dae Gwin
Yoon, Sun-Woo
Kim, Ji Hyung
Choi, Yong Gun
Kang, Shien-Young
Kim, Hye Kwon
Isolation and characterization of novel bat paramyxovirus B16-40 potentially belonging to the proposed genus Shaanvirus
title Isolation and characterization of novel bat paramyxovirus B16-40 potentially belonging to the proposed genus Shaanvirus
title_full Isolation and characterization of novel bat paramyxovirus B16-40 potentially belonging to the proposed genus Shaanvirus
title_fullStr Isolation and characterization of novel bat paramyxovirus B16-40 potentially belonging to the proposed genus Shaanvirus
title_full_unstemmed Isolation and characterization of novel bat paramyxovirus B16-40 potentially belonging to the proposed genus Shaanvirus
title_short Isolation and characterization of novel bat paramyxovirus B16-40 potentially belonging to the proposed genus Shaanvirus
title_sort isolation and characterization of novel bat paramyxovirus b16-40 potentially belonging to the proposed genus shaanvirus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105681/
https://www.ncbi.nlm.nih.gov/pubmed/30135435
http://dx.doi.org/10.1038/s41598-018-30319-7
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