Cargando…

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

Cyclic GMP-AMP synthase (cGAS) senses double-strand (ds) DNA in the cytosol and then catalyzes synthesis of the second messenger cGAMP, which activates the adaptor MITA/STING to initiate innate antiviral response. How cGAS activity is regulated remains enigmatic. Here, we identify ZCCHC3, a CCHC-typ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lian, Huan, Wei, Jin, Zang, Ru, Ye, Wen, Yang, Qing, Zhang, Xia-Nan, Chen, Yun-Da, Fu, Yu-Zhi, Hu, Ming-Ming, Lei, Cao-Qi, Luo, Wei-Wei, Li, Shu, Shu, Hong-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105683/ https://www.ncbi.nlm.nih.gov/pubmed/30135424 http://dx.doi.org/10.1038/s41467-018-05559-w

Ejemplares similares

Author Correction: ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
por: Lian, Huan, et al.
Publicado: (2021)

Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response
por: Chu, Lei, et al.
Publicado: (2021)

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
por: Lama, Lodoe, et al.
Publicado: (2019)

Wiskott-Aldrich syndrome protein restricts cGAS/STING activation by dsDNA immune complexes
por: Piperno, Giulia Maria, et al.
Publicado: (2020)

Allosteric coupling between Mn(2+) and dsDNA controls the catalytic efficiency and fidelity of cGAS
por: Hooy, Richard M, et al.
Publicado: (2020)

ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3
por: Zang, Ru, et al.
Publicado: (2020)

The Effects of Flexibility on dsDNA–dsDNA Interactions
por: Chen, Chuanying, et al.
Publicado: (2022)

Identification of cGAS as an innate immune sensor of extracellular bacterium Pseudomonas aeruginosa
por: Zhou, Chuan-min, et al.
Publicado: (2020)

Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway
por: Davis, Shamara E., et al.
Publicado: (2019)

DNA sensor cGAS-mediated immune recognition
por: Xia, Pengyan, et al.
Publicado: (2016)

Sensitive Fluorescent Sensor for Recognition of HIV-1 dsDNA by Using Glucose Oxidase and Triplex DNA
por: Li, Yubin, et al.
Publicado: (2018)

Viral nanomotors for packaging of dsDNA and dsRNA
por: Guo, Peixuan, et al.
Publicado: (2007)

Endocytosis triggers V-ATPase-SYK–mediated priming of cGAS activation and innate immune response
por: Yang, Yu-Lin, et al.
Publicado: (2022)

Changes in the tension in dsDNA alter the conformation of RecA bound to dsDNA–RecA filaments
por: Conover, Alyson J., et al.
Publicado: (2011)

Force spectroscopy and fluorescence microscopy of dsDNA–YOYO-1 complexes: implications for the structure of dsDNA in the overstretching region
por: Murade, Chandrashekhar U., et al.
Publicado: (2010)

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response
por: Li, Mi, et al.
Publicado: (2020)

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
por: Sun, Xiaona, et al.
Publicado: (2020)

Protein chainmail variants in dsDNA viruses
por: Zhou, Z. Hong, et al.
Publicado: (2015)

Anti-dsDNA Antibodies are one of the many autoantibodies in systemic lupus erythematosus
por: Fu, Shu Man, et al.
Publicado: (2015)

Clinical Comparison of QUANTA Flash dsDNA Chemiluminescent Immunoassay with Four Current Assays for the Detection of Anti-dsDNA Autoantibodies
por: Infantino, Maria, et al.
Publicado: (2015)

SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA
por: Wei, Jin, et al.
Publicado: (2018)

Mitotic inactivation of the cGAS‒MITA/STING pathways
por: Zhong, Li, et al.
Publicado: (2021)

Sequential action of ATPase, ATP, ADP, Pi and dsDNA in procapsid-free system to enlighten mechanism in viral dsDNA packaging
por: Schwartz, Chad, et al.
Publicado: (2012)

Torque-limited RecA polymerization on dsDNA
por: van der Heijden, Thijn, et al.
Publicado: (2005)

Torque-limited RecA polymerization on dsDNA
por: van der Heijden, Thijn, et al.
Publicado: (2005)

Structure and Dynamics of dsDNA in Cell-like Environments
por: Singh, Amar, et al.
Publicado: (2022)

Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis
por: Zhong, Li, et al.
Publicado: (2020)

Anti-dsDNA-NcX ELISA: dsDNA-loaded nucleosomes improve diagnosis and monitoring of disease activity in systemic lupus erythematosus
por: Biesen, Robert, et al.
Publicado: (2011)

RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses
por: Liu, Zhao-Shan, et al.
Publicado: (2018)

The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses
por: Kozlowski, Elyse, et al.
Publicado: (2017)

Role of Post-Translational Modifications of cGAS in Innate Immunity
por: Wu, Yakun, et al.
Publicado: (2020)

The dsDNA, Anti-dsDNA Antibody, and Lupus Nephritis: What We Agree on, What Must Be Done, and What the Best Strategy Forward Could Be
por: Rekvig, Ole Petter
Publicado: (2019)

m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner
por: Balzarolo, Melania, et al.
Publicado: (2021)

Antibodies Elicited in Response to EBNA-1 May Cross-React with dsDNA
por: Yadav, Pragya, et al.
Publicado: (2011)

Binding fullerenol C(60)(OH)(24) to dsDNA
por: Pinteala, Mariana, et al.
Publicado: (2009)

Infliximab induced anti-dsDNA: characteristics of autoantibody response
por: Charles, PJ, et al.
Publicado: (2002)

Sizing femtogram amounts of dsDNA by single-molecule counting
por: Torchinsky, Dmitry, et al.
Publicado: (2016)

Melting dynamics of short dsDNA chains in saline solutions
por: He, Yichen, et al.
Publicado: (2015)

A novel pathway to detect and cope with exogenous dsDNA
por: Kobayashi, Shouhei, et al.
Publicado: (2015)

DSBCapture: in situ capture and direct sequencing of dsDNA breaks
por: Lensing, Stefanie V., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_pl4bturcptd1o52ccmf0rb13cc