In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus

Cryptococcal meningitis (CM), caused primarily by Cryptococcus neoformans, is uniformly fatal if not treated. Treatment options are limited, especially in resource-poor geographical regions, and mortality rates remain high despite current therapies. Here we evaluated the in vitro and in vivo activit...

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Detalles Bibliográficos
Autores principales: Shaw, Karen Joy, Schell, Wiley A., Covel, Jonathan, Duboc, Gisele, Giamberardino, C., Kapoor, Mili, Moloney, Molly, Soltow, Quinlyn A., Tenor, Jennifer L., Toffaletti, Dena L., Trzoss, Michael, Webb, Peter, Perfect, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105804/
https://www.ncbi.nlm.nih.gov/pubmed/29891599
http://dx.doi.org/10.1128/AAC.00523-18

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