Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae

The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) Enterobacteriaceae, was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR Enterobacteriaceae isolate...

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Autores principales: Thwaites, M., Hall, D., Shinabarger, D., Serio, A. W., Krause, K. M., Marra, A., Pillar, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105851/
https://www.ncbi.nlm.nih.gov/pubmed/29866876
http://dx.doi.org/10.1128/AAC.00236-18
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author Thwaites, M.
Hall, D.
Shinabarger, D.
Serio, A. W.
Krause, K. M.
Marra, A.
Pillar, C.
author_facet Thwaites, M.
Hall, D.
Shinabarger, D.
Serio, A. W.
Krause, K. M.
Marra, A.
Pillar, C.
author_sort Thwaites, M.
collection PubMed
description The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) Enterobacteriaceae, was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR Enterobacteriaceae isolates with characterized aminoglycoside and β-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC(50/90) of 0.5/4 μg/ml and sustained 3-log(10) kill against MDR Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp.
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spelling pubmed-61058512018-08-24 Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae Thwaites, M. Hall, D. Shinabarger, D. Serio, A. W. Krause, K. M. Marra, A. Pillar, C. Antimicrob Agents Chemother Clinical Therapeutics The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) Enterobacteriaceae, was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR Enterobacteriaceae isolates with characterized aminoglycoside and β-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC(50/90) of 0.5/4 μg/ml and sustained 3-log(10) kill against MDR Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp. American Society for Microbiology 2018-07-27 /pmc/articles/PMC6105851/ /pubmed/29866876 http://dx.doi.org/10.1128/AAC.00236-18 Text en Copyright © 2018 Thwaites et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Therapeutics
Thwaites, M.
Hall, D.
Shinabarger, D.
Serio, A. W.
Krause, K. M.
Marra, A.
Pillar, C.
Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae
title Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae
title_full Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae
title_fullStr Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae
title_full_unstemmed Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae
title_short Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae
title_sort evaluation of the bactericidal activity of plazomicin and comparators against multidrug-resistant enterobacteriaceae
topic Clinical Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105851/
https://www.ncbi.nlm.nih.gov/pubmed/29866876
http://dx.doi.org/10.1128/AAC.00236-18
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