Application of Displacement Chromatography to Online Two-Dimensional Liquid Chromatography Coupled to Tandem Mass Spectrometry Improves Peptide Separation Efficiency and Detectability for the Analysis of Complex Proteomes

[Image: see text] The complexity of mammalian proteomes is a challenge in bottom-up proteomics. For a comprehensive proteome analysis, multidimensional separation strategies are necessary. Online two-dimensional liquid chromatography–tandem mass spectrometry (2D-LC-MS/MS) combining strong cation exc...

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Detalles Bibliográficos
Autores principales: Kwiatkowski, Marcel, Krösser, Dennis, Wurlitzer, Marcus, Steffen, Pascal, Barcaru, Andrei, Krisp, Christoph, Horvatovich, Péter, Bischoff, Rainer, Schlüter, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106052/
https://www.ncbi.nlm.nih.gov/pubmed/30014690
http://dx.doi.org/10.1021/acs.analchem.8b02189

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