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Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma

Epstein-Barr virus (EBV) is associated with several B and epithelial cell cancers. EBV-encoded latent membrane protein 2A (LMP2A) contributes to cellular transformation by mimicking B cell receptor signaling. LMP2A/MYC double transgenic mice develop splenomegaly and B cell lymphoma much faster than...

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Detalles Bibliográficos
Autores principales:	Cen, Osman, Kannan, Karuppiah, Huck Sappal, Jessica, Yu, Jie, Zhang, Mengkun, Arikan, Muzaffer, Ucur, Ali, Ustek, Duran, Cen, Yeter, Gordon, Leo, Longnecker, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106053/ https://www.ncbi.nlm.nih.gov/pubmed/30135222 http://dx.doi.org/10.1128/mSphereDirect.00378-18

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