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Two phytotoxic azaphilone derivatives from Chaetomium globosum, a fungal endophyte isolated from Amaranthus viridis leaves
A fungal endophyte isolated from the leaves of the allelopathic plant Amaranthus viridis of the family Amaranthaceae was identified as Chaetomium globosum through molecular means using internal transcribed spacer (ITS) region of rDNA gene. This is the first report of the isolation of C. globosum fro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106071/ https://www.ncbi.nlm.nih.gov/pubmed/30151324 http://dx.doi.org/10.1080/21501203.2015.1089332 |
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author | Piyasena, K.G. Nelum P. Wickramarachchi, W.A.R.T. Kumar, N. Savitri Jayasinghe, Lalith Fujimoto, Yoshinori |
author_facet | Piyasena, K.G. Nelum P. Wickramarachchi, W.A.R.T. Kumar, N. Savitri Jayasinghe, Lalith Fujimoto, Yoshinori |
author_sort | Piyasena, K.G. Nelum P. |
collection | PubMed |
description | A fungal endophyte isolated from the leaves of the allelopathic plant Amaranthus viridis of the family Amaranthaceae was identified as Chaetomium globosum through molecular means using internal transcribed spacer (ITS) region of rDNA gene. This is the first report of the isolation of C. globosum from Amaranthaceae. Chromatographic separation of the EtOAc extract of the fungal fermentation in potato dextrose broth yielded two known chlorine-containing azaphilone derivatives, chaetomugilin D (1) and chaetomugilin J (2). Compounds 1 and 2 were found to show phytotoxic activity in the lettuce (Lactuca sativa) seed germination bioassay. The IC(50) values of 1 and 2 for root growth inhibition were 24.2 and 22.6 ppm, respectively, while IC(50) values for shoot growth inhibition were 27.8 and 21.9 ppm, respectively. Phytotoxic activities of the chaetomugilin group of compounds have been reported for the first time, although their antifungal, antimicrobial and cytotoxic activities are known. |
format | Online Article Text |
id | pubmed-6106071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-61060712018-08-27 Two phytotoxic azaphilone derivatives from Chaetomium globosum, a fungal endophyte isolated from Amaranthus viridis leaves Piyasena, K.G. Nelum P. Wickramarachchi, W.A.R.T. Kumar, N. Savitri Jayasinghe, Lalith Fujimoto, Yoshinori Mycology Articles A fungal endophyte isolated from the leaves of the allelopathic plant Amaranthus viridis of the family Amaranthaceae was identified as Chaetomium globosum through molecular means using internal transcribed spacer (ITS) region of rDNA gene. This is the first report of the isolation of C. globosum from Amaranthaceae. Chromatographic separation of the EtOAc extract of the fungal fermentation in potato dextrose broth yielded two known chlorine-containing azaphilone derivatives, chaetomugilin D (1) and chaetomugilin J (2). Compounds 1 and 2 were found to show phytotoxic activity in the lettuce (Lactuca sativa) seed germination bioassay. The IC(50) values of 1 and 2 for root growth inhibition were 24.2 and 22.6 ppm, respectively, while IC(50) values for shoot growth inhibition were 27.8 and 21.9 ppm, respectively. Phytotoxic activities of the chaetomugilin group of compounds have been reported for the first time, although their antifungal, antimicrobial and cytotoxic activities are known. Taylor & Francis 2015-09-22 /pmc/articles/PMC6106071/ /pubmed/30151324 http://dx.doi.org/10.1080/21501203.2015.1089332 Text en © 2015 The Author(s). Published by Taylor & Francis http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Piyasena, K.G. Nelum P. Wickramarachchi, W.A.R.T. Kumar, N. Savitri Jayasinghe, Lalith Fujimoto, Yoshinori Two phytotoxic azaphilone derivatives from Chaetomium globosum, a fungal endophyte isolated from Amaranthus viridis leaves |
title | Two phytotoxic azaphilone derivatives from Chaetomium globosum, a fungal endophyte isolated from Amaranthus viridis leaves |
title_full | Two phytotoxic azaphilone derivatives from Chaetomium globosum, a fungal endophyte isolated from Amaranthus viridis leaves |
title_fullStr | Two phytotoxic azaphilone derivatives from Chaetomium globosum, a fungal endophyte isolated from Amaranthus viridis leaves |
title_full_unstemmed | Two phytotoxic azaphilone derivatives from Chaetomium globosum, a fungal endophyte isolated from Amaranthus viridis leaves |
title_short | Two phytotoxic azaphilone derivatives from Chaetomium globosum, a fungal endophyte isolated from Amaranthus viridis leaves |
title_sort | two phytotoxic azaphilone derivatives from chaetomium globosum, a fungal endophyte isolated from amaranthus viridis leaves |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106071/ https://www.ncbi.nlm.nih.gov/pubmed/30151324 http://dx.doi.org/10.1080/21501203.2015.1089332 |
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