Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs

Infection with Ross River virus (RRV) causes debilitating polyarthritis and arthralgia in individuals. Alphaviruses are highly sensitive to type I interferon (IFN). Mutations at the conserved P3 position of the cleavage site between nonstructural protein 1 (nsP1) and nsP2 (1/2 site) modulate type I...

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Detalles Bibliográficos
Autores principales: Liu, Xiang, Mutso, Margit, Utt, Age, Lepland, Anni, Herrero, Lara J., Taylor, Adam, Bettadapura, Jayaram, Rudd, Penny A., Merits, Andres, Mahalingam, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106088/
https://www.ncbi.nlm.nih.gov/pubmed/30131356
http://dx.doi.org/10.1128/mBio.00044-18

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