Fluconazole-Resistant Candida parapsilosis Bloodstream Isolates with Y132F Mutation in ERG11 Gene, South Korea

We recently observed the emergence of fluconazole-resistant Candida parapsilosis bloodstream isolates harboring a Y132F substitution in Erg11p in South Korea. These Y132F isolates had a higher propensity to cause clonal transmission than other fluconazole-resistant isolates and persisted within hosp...

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Detalles Bibliográficos
Autores principales: Choi, Yong Jun, Kim, Yae-Jean, Yong, Dongeun, Byun, Jung-Hyun, Kim, Taek Soo, Chang, Yun Sil, Choi, Min Ji, Byeon, Seung Ah, Won, Eun Jeong, Kim, Soo Hyun, Shin, Myung Geun, Shin, Jong Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106402/
https://www.ncbi.nlm.nih.gov/pubmed/30124412
http://dx.doi.org/10.3201/eid2409.180625
Descripción
Sumario:We recently observed the emergence of fluconazole-resistant Candida parapsilosis bloodstream isolates harboring a Y132F substitution in Erg11p in South Korea. These Y132F isolates had a higher propensity to cause clonal transmission than other fluconazole-resistant isolates and persisted within hospitals for several years, as revealed by microsatellite typing.

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