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Detection of a novel, primate-specific ‘kill switch’ tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53
The activation of TP53 is well known to exert tumor suppressive effects. We have detected a primate-specific adrenal androgen-mediated tumor suppression system in which circulating DHEAS is converted to DHEA specifically in cells in which TP53 has been inactivated. DHEA is an uncompetitive inhibitor...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Bioscientifica Ltd
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106910/ https://www.ncbi.nlm.nih.gov/pubmed/29941676 http://dx.doi.org/10.1530/ERC-18-0241 |