Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus

BACKGROUND: Very late antigen 4 (VLA-4; integrin α4β1) is critical for transmigration of T helper (T(H)) 1 cells into the central nervous system (CNS) under inflammatory conditions such as multiple sclerosis (MS). We have previously shown that VLA-4 and melanoma cell adhesion molecule (MCAM) are imp...

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Detalles Bibliográficos
Autores principales: Breuer, Johanna, Korpos, Eva, Hannocks, Melanie-Jane, Schneider-Hohendorf, Tilman, Song, Jian, Zondler, Lisa, Herich, Sebastian, Flanagan, Ken, Korn, Thomas, Zarbock, Alexander, Kuhlmann, Tanja, Sorokin, Lydia, Wiendl, Heinz, Schwab, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106934/
https://www.ncbi.nlm.nih.gov/pubmed/30134924
http://dx.doi.org/10.1186/s12974-018-1276-4

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