Cysteine proteases during larval migration and development of helminths in their final host

Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helmi...

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Detalles Bibliográficos
Autores principales: Grote, Alexandra, Caffrey, Conor R., Rebello, Karina M., Smith, David, Dalton, John P., Lustigman, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107106/
https://www.ncbi.nlm.nih.gov/pubmed/30138448
http://dx.doi.org/10.1371/journal.pntd.0005919
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author Grote, Alexandra
Caffrey, Conor R.
Rebello, Karina M.
Smith, David
Dalton, John P.
Lustigman, Sara
author_facet Grote, Alexandra
Caffrey, Conor R.
Rebello, Karina M.
Smith, David
Dalton, John P.
Lustigman, Sara
author_sort Grote, Alexandra
collection PubMed
description Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis.
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spelling pubmed-61071062018-08-30 Cysteine proteases during larval migration and development of helminths in their final host Grote, Alexandra Caffrey, Conor R. Rebello, Karina M. Smith, David Dalton, John P. Lustigman, Sara PLoS Negl Trop Dis Review Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis. Public Library of Science 2018-08-23 /pmc/articles/PMC6107106/ /pubmed/30138448 http://dx.doi.org/10.1371/journal.pntd.0005919 Text en © 2018 Grote et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Grote, Alexandra
Caffrey, Conor R.
Rebello, Karina M.
Smith, David
Dalton, John P.
Lustigman, Sara
Cysteine proteases during larval migration and development of helminths in their final host
title Cysteine proteases during larval migration and development of helminths in their final host
title_full Cysteine proteases during larval migration and development of helminths in their final host
title_fullStr Cysteine proteases during larval migration and development of helminths in their final host
title_full_unstemmed Cysteine proteases during larval migration and development of helminths in their final host
title_short Cysteine proteases during larval migration and development of helminths in their final host
title_sort cysteine proteases during larval migration and development of helminths in their final host
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107106/
https://www.ncbi.nlm.nih.gov/pubmed/30138448
http://dx.doi.org/10.1371/journal.pntd.0005919
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