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A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells
A model of B cell affinity selection is proposed, and an explanation of peripheral tolerance mechanisms through antibody repertoire editing is presented. We show that affinity discrimination between B cells is driven by a competition between obtaining T cell help and removal of B cells from the ligh...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107130/ https://www.ncbi.nlm.nih.gov/pubmed/30138347 http://dx.doi.org/10.1371/journal.pone.0200241 |