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Time-domain THz spectroscopy of the characteristics of hydroxyapatite provides a signature of heating in bone tissue

Because of the importance of bone in the biomedical, forensic and archaeological contexts, new investigation techniques are constantly required to better characterize bone ultrastructure. In the present paper, we provide an extended investigation of the vibrational features of bone tissue in the 0.1...

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Autores principales: Plazanet, Marie, Tasseva, Jordanka, Bartolini, Paolo, Taschin, Andrea, Torre, Renato, Combes, Christèle, Rey, Christian, Di Michele, Alessandro, Verezhak, Mariana, Gourrier, Aurelien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107136/
https://www.ncbi.nlm.nih.gov/pubmed/30138314
http://dx.doi.org/10.1371/journal.pone.0201745
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author Plazanet, Marie
Tasseva, Jordanka
Bartolini, Paolo
Taschin, Andrea
Torre, Renato
Combes, Christèle
Rey, Christian
Di Michele, Alessandro
Verezhak, Mariana
Gourrier, Aurelien
author_facet Plazanet, Marie
Tasseva, Jordanka
Bartolini, Paolo
Taschin, Andrea
Torre, Renato
Combes, Christèle
Rey, Christian
Di Michele, Alessandro
Verezhak, Mariana
Gourrier, Aurelien
author_sort Plazanet, Marie
collection PubMed
description Because of the importance of bone in the biomedical, forensic and archaeological contexts, new investigation techniques are constantly required to better characterize bone ultrastructure. In the present paper, we provide an extended investigation of the vibrational features of bone tissue in the 0.1-3 THz frequency range by time-domain THz spectroscopy. Their assignment is supported by a combination of X-ray diffraction and DFT-normal modes calculations. We investigate the effect of heating on bone tissue and synthetic calcium-phosphates compounds with close structure and composition to bone mineral, including stoichiometric and non-stoichiometric hydroxyapatite (HA), tricalcium phosphate, calcium pyrophosphate and tetracalcium phosphate. We thus demonstrate that the narrow vibrational mode at 2.1 THz in bone samples exposed to thermal treatment above 750 °C arises from a lattice mode of stoichiometric HA. This feature is also observed in the other synthetic compounds, although weaker or broader, but is completely smeared out in the non-stoichiometric HA, close to natural bone mineral composition, or in synthetic poorly crystalline HA powder. The THz spectral range therefore provides a clear signature of the crystalline state of the investigated bone tissue and could, therefore be used to monitor or identify structural transitions occurring in bone upon heating.
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spelling pubmed-61071362018-08-30 Time-domain THz spectroscopy of the characteristics of hydroxyapatite provides a signature of heating in bone tissue Plazanet, Marie Tasseva, Jordanka Bartolini, Paolo Taschin, Andrea Torre, Renato Combes, Christèle Rey, Christian Di Michele, Alessandro Verezhak, Mariana Gourrier, Aurelien PLoS One Research Article Because of the importance of bone in the biomedical, forensic and archaeological contexts, new investigation techniques are constantly required to better characterize bone ultrastructure. In the present paper, we provide an extended investigation of the vibrational features of bone tissue in the 0.1-3 THz frequency range by time-domain THz spectroscopy. Their assignment is supported by a combination of X-ray diffraction and DFT-normal modes calculations. We investigate the effect of heating on bone tissue and synthetic calcium-phosphates compounds with close structure and composition to bone mineral, including stoichiometric and non-stoichiometric hydroxyapatite (HA), tricalcium phosphate, calcium pyrophosphate and tetracalcium phosphate. We thus demonstrate that the narrow vibrational mode at 2.1 THz in bone samples exposed to thermal treatment above 750 °C arises from a lattice mode of stoichiometric HA. This feature is also observed in the other synthetic compounds, although weaker or broader, but is completely smeared out in the non-stoichiometric HA, close to natural bone mineral composition, or in synthetic poorly crystalline HA powder. The THz spectral range therefore provides a clear signature of the crystalline state of the investigated bone tissue and could, therefore be used to monitor or identify structural transitions occurring in bone upon heating. Public Library of Science 2018-08-23 /pmc/articles/PMC6107136/ /pubmed/30138314 http://dx.doi.org/10.1371/journal.pone.0201745 Text en © 2018 Plazanet et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Plazanet, Marie
Tasseva, Jordanka
Bartolini, Paolo
Taschin, Andrea
Torre, Renato
Combes, Christèle
Rey, Christian
Di Michele, Alessandro
Verezhak, Mariana
Gourrier, Aurelien
Time-domain THz spectroscopy of the characteristics of hydroxyapatite provides a signature of heating in bone tissue
title Time-domain THz spectroscopy of the characteristics of hydroxyapatite provides a signature of heating in bone tissue
title_full Time-domain THz spectroscopy of the characteristics of hydroxyapatite provides a signature of heating in bone tissue
title_fullStr Time-domain THz spectroscopy of the characteristics of hydroxyapatite provides a signature of heating in bone tissue
title_full_unstemmed Time-domain THz spectroscopy of the characteristics of hydroxyapatite provides a signature of heating in bone tissue
title_short Time-domain THz spectroscopy of the characteristics of hydroxyapatite provides a signature of heating in bone tissue
title_sort time-domain thz spectroscopy of the characteristics of hydroxyapatite provides a signature of heating in bone tissue
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107136/
https://www.ncbi.nlm.nih.gov/pubmed/30138314
http://dx.doi.org/10.1371/journal.pone.0201745
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