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Multidimensional impact of breast cancer screening: Results of the multicenter prospective optisoins01 study

Breast cancer (BC) screening has been developed to detect earlier stage tumors associated with better prognosis. The aim of study was to evaluate the impact of BC screening on therapeutic management of patients with first operable BC, and on costs, patients’ needs, and working life. OPTISOINS01 was...

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Autores principales: Cariou, Amélie, Rouzier, Roman, Baffert, Sandrine, Soilly, Anne-Laure, Hequet, Delphine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107193/
https://www.ncbi.nlm.nih.gov/pubmed/30138470
http://dx.doi.org/10.1371/journal.pone.0202385
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author Cariou, Amélie
Rouzier, Roman
Baffert, Sandrine
Soilly, Anne-Laure
Hequet, Delphine
author_facet Cariou, Amélie
Rouzier, Roman
Baffert, Sandrine
Soilly, Anne-Laure
Hequet, Delphine
author_sort Cariou, Amélie
collection PubMed
description Breast cancer (BC) screening has been developed to detect earlier stage tumors associated with better prognosis. The aim of study was to evaluate the impact of BC screening on therapeutic management of patients with first operable BC, and on costs, patients’ needs, and working life. OPTISOINS01 was a multicenter, prospective observational study which aimed to identify the main care pathway of early BC. Among patients aged from 50 to 74 years-old, 2 groups were defined: the “Clinical signs” group and the "Screening" group (national organized screening and individual screening). We compared between these 2 groups: locoregional and systemic treatments, direct medical and non-medical costs from a National Health Insurance perspective, patients’ needs assessed by the validated SCNS-BR8 “breast cancer” module of the SCNS-SF34 supportive care needs survey and the duration of sick leave. The “Clinical signs” group included 89 patients, while the”Screening” group included 290 patients. More axillary lymph node dissections and radical breast surgery were performed in the “Clinical signs”. The rate of adjuvant chemotherapy was dramatically higher in the “Clinical signs” group. The median direct medical costs of the “Screening” group were €11,860 (€3,643-€41,030) per year and per patient, much lower than in the “Clinical signs” group (€14,940; €5,317-€41,070). Finally, needs specifically assessed by the SCNS-BR8 questionnaire were significantly higher for the postoperative and post-adjuvant periods in the “Clinical signs” group. This study highlighted the benefit of BC screening in terms of reduced therapies and positive impact on work and social life.
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spelling pubmed-61071932018-08-30 Multidimensional impact of breast cancer screening: Results of the multicenter prospective optisoins01 study Cariou, Amélie Rouzier, Roman Baffert, Sandrine Soilly, Anne-Laure Hequet, Delphine PLoS One Research Article Breast cancer (BC) screening has been developed to detect earlier stage tumors associated with better prognosis. The aim of study was to evaluate the impact of BC screening on therapeutic management of patients with first operable BC, and on costs, patients’ needs, and working life. OPTISOINS01 was a multicenter, prospective observational study which aimed to identify the main care pathway of early BC. Among patients aged from 50 to 74 years-old, 2 groups were defined: the “Clinical signs” group and the "Screening" group (national organized screening and individual screening). We compared between these 2 groups: locoregional and systemic treatments, direct medical and non-medical costs from a National Health Insurance perspective, patients’ needs assessed by the validated SCNS-BR8 “breast cancer” module of the SCNS-SF34 supportive care needs survey and the duration of sick leave. The “Clinical signs” group included 89 patients, while the”Screening” group included 290 patients. More axillary lymph node dissections and radical breast surgery were performed in the “Clinical signs”. The rate of adjuvant chemotherapy was dramatically higher in the “Clinical signs” group. The median direct medical costs of the “Screening” group were €11,860 (€3,643-€41,030) per year and per patient, much lower than in the “Clinical signs” group (€14,940; €5,317-€41,070). Finally, needs specifically assessed by the SCNS-BR8 questionnaire were significantly higher for the postoperative and post-adjuvant periods in the “Clinical signs” group. This study highlighted the benefit of BC screening in terms of reduced therapies and positive impact on work and social life. Public Library of Science 2018-08-23 /pmc/articles/PMC6107193/ /pubmed/30138470 http://dx.doi.org/10.1371/journal.pone.0202385 Text en © 2018 Cariou et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cariou, Amélie
Rouzier, Roman
Baffert, Sandrine
Soilly, Anne-Laure
Hequet, Delphine
Multidimensional impact of breast cancer screening: Results of the multicenter prospective optisoins01 study
title Multidimensional impact of breast cancer screening: Results of the multicenter prospective optisoins01 study
title_full Multidimensional impact of breast cancer screening: Results of the multicenter prospective optisoins01 study
title_fullStr Multidimensional impact of breast cancer screening: Results of the multicenter prospective optisoins01 study
title_full_unstemmed Multidimensional impact of breast cancer screening: Results of the multicenter prospective optisoins01 study
title_short Multidimensional impact of breast cancer screening: Results of the multicenter prospective optisoins01 study
title_sort multidimensional impact of breast cancer screening: results of the multicenter prospective optisoins01 study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107193/
https://www.ncbi.nlm.nih.gov/pubmed/30138470
http://dx.doi.org/10.1371/journal.pone.0202385
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