Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice

During Coxsackievirus B3 (CVB3) infection hepatitis is a potentially life threatening complication, particularly in newborns. Studies with type I interferon (IFN-I) receptor (IFNAR)-deficient mice revealed a key role of the IFN-I axis in the protection against CVB3 infection, whereas the source of I...

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Detalles Bibliográficos
Autores principales: Koestner, Wolfgang, Spanier, Julia, Klause, Tanja, Tegtmeyer, Pia-K., Becker, Jennifer, Herder, Vanessa, Borst, Katharina, Todt, Daniel, Lienenklaus, Stefan, Gerhauser, Ingo, Detje, Claudia N., Geffers, Robert, Langereis, Martijn A., Vondran, Florian W. R., Yuan, Qinggong, van Kuppeveld, Frank J. M., Ott, Michael, Staeheli, Peter, Steinmann, Eike, Baumgärtner, Wolfgang, Wacker, Frank, Kalinke, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107283/
https://www.ncbi.nlm.nih.gov/pubmed/30075026
http://dx.doi.org/10.1371/journal.ppat.1007235

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