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Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease

Those patients with perianal Crohn’s disease or ulcerative colitis experience a difficult to treat disease process with a delayed state and often inability to heal despite current therapies. The approaches currently used to treat these patients with corticosteroids, antibiotics, immunomodulators, an...

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Autores principales: Dailey, Francis E, Turse, Erica P, Naseer, Maliha, Bragg, Jack D, Tahan, Veysel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107517/
https://www.ncbi.nlm.nih.gov/pubmed/30148075
http://dx.doi.org/10.5500/wjt.v8.i4.97
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author Dailey, Francis E
Turse, Erica P
Naseer, Maliha
Bragg, Jack D
Tahan, Veysel
author_facet Dailey, Francis E
Turse, Erica P
Naseer, Maliha
Bragg, Jack D
Tahan, Veysel
author_sort Dailey, Francis E
collection PubMed
description Those patients with perianal Crohn’s disease or ulcerative colitis experience a difficult to treat disease process with a delayed state and often inability to heal despite current therapies. The approaches currently used to treat these patients with corticosteroids, antibiotics, immunomodulators, anti-tumor necrosis factor-α drug, and surgical repair are limited in their healing ability. This review presents all current literature since emergence in the early 2000s of stem cell therapy for patients with perianal inflammatory bowel disease and analyzes the efficacy, outcomes and safety within these studies.
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spelling pubmed-61075172018-08-24 Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease Dailey, Francis E Turse, Erica P Naseer, Maliha Bragg, Jack D Tahan, Veysel World J Transplant Minireviews Those patients with perianal Crohn’s disease or ulcerative colitis experience a difficult to treat disease process with a delayed state and often inability to heal despite current therapies. The approaches currently used to treat these patients with corticosteroids, antibiotics, immunomodulators, anti-tumor necrosis factor-α drug, and surgical repair are limited in their healing ability. This review presents all current literature since emergence in the early 2000s of stem cell therapy for patients with perianal inflammatory bowel disease and analyzes the efficacy, outcomes and safety within these studies. Baishideng Publishing Group Inc 2018-08-09 2018-08-09 /pmc/articles/PMC6107517/ /pubmed/30148075 http://dx.doi.org/10.5500/wjt.v8.i4.97 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Dailey, Francis E
Turse, Erica P
Naseer, Maliha
Bragg, Jack D
Tahan, Veysel
Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease
title Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease
title_full Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease
title_fullStr Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease
title_full_unstemmed Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease
title_short Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease
title_sort review of stem cells as promising therapy for perianal disease in inflammatory bowel disease
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107517/
https://www.ncbi.nlm.nih.gov/pubmed/30148075
http://dx.doi.org/10.5500/wjt.v8.i4.97
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