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Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V

N-acetylglucosaminyltransferase-V (GnT-V) alters the structure of specific N-glycans by modifying α1-6-linked mannose with a β1-6-linked N-acetylglucosamine branch. β1-6 branch formation on cell surface receptors accelerates cancer metastasis, making GnT-V a promising target for drug development. Ho...

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Detalles Bibliográficos
Autores principales:	Nagae, Masamichi, Kizuka, Yasuhiko, Mihara, Emiko, Kitago, Yu, Hanashima, Shinya, Ito, Yukishige, Takagi, Junichi, Taniguchi, Naoyuki, Yamaguchi, Yoshiki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107550/ https://www.ncbi.nlm.nih.gov/pubmed/30140003 http://dx.doi.org/10.1038/s41467-018-05931-w

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