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Effectiveness of EGFR/HER2-targeted drugs is influenced by the downstream interaction shifts of PTPIP51 in HER2-amplified breast cancer cells

Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20–30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled to a more aggressive and invasive growth of the cancer cells. Recently developed tyrosine k...

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Detalles Bibliográficos
Autores principales: Dietel, Eric, Brobeil, Alexander, Tag, Claudia, Gattenloehner, Stefan, Wimmer, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107558/
https://www.ncbi.nlm.nih.gov/pubmed/30139932
http://dx.doi.org/10.1038/s41389-018-0075-1