Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery and penetration. Activated pancreatic stellate cells (PSCs) play a key role in establishing this unique pathological...

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Detalles Bibliográficos
Autores principales: Han, Xuexiang, Li, Yiye, Xu, Ying, Zhao, Xiao, Zhang, Yinlong, Yang, Xiao, Wang, Yongwei, Zhao, Ruifang, Anderson, Gregory J., Zhao, Yuliang, Nie, Guangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107580/
https://www.ncbi.nlm.nih.gov/pubmed/30139933
http://dx.doi.org/10.1038/s41467-018-05906-x

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