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Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance
Memory is indispensable for normal cognitive functioning, and the ability to store and retrieve information is central to mental health and disease. The molecular mechanisms underlying complex memory functions are largely unknown, but multiple genome-wide association studies suggest that gene regula...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107676/ https://www.ncbi.nlm.nih.gov/pubmed/30139959 http://dx.doi.org/10.1038/s41598-018-30898-5 |
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author | Akkouh, Ibrahim A. Ueland, Torill Andreassen, Ole A. Brattbakk, Hans-Richard Steen, Vidar M. Hughes, Timothy Djurovic, Srdjan |
author_facet | Akkouh, Ibrahim A. Ueland, Torill Andreassen, Ole A. Brattbakk, Hans-Richard Steen, Vidar M. Hughes, Timothy Djurovic, Srdjan |
author_sort | Akkouh, Ibrahim A. |
collection | PubMed |
description | Memory is indispensable for normal cognitive functioning, and the ability to store and retrieve information is central to mental health and disease. The molecular mechanisms underlying complex memory functions are largely unknown, but multiple genome-wide association studies suggest that gene regulation may play a role in memory dysfunction. We performed a global gene expression analysis using a large and balanced case-control sample (n = 754) consisting of healthy controls and schizophrenia and bipolar disorder patients. Our aim was to discover genes that are differentially expressed in relation to memory performance. Gene expression in blood was measured using Illumina HumanHT-12 v4 Expression BeadChip and memory performance was assessed with the updated California Verbal Learning Test (CVLT-II). We found that elevated expression of the vitamin B12-related gene TCN1 (haptocorrin) was significantly associated with poorer memory performance after correcting for multiple testing (β = −1.50, p = 3.75e-08). This finding was validated by quantitative real-time PCR and followed up with additional analyses adjusting for confounding variables. We also attempted to replicate the finding in an independent case-control sample (n = 578). The relationship between TCN1 expression and memory impairment was comparable to that of important determinants of memory function such as age and sex, suggesting that TCN1 could be a clinically relevant marker of memory performance. Thus, we identify TCN1 as a novel genetic finding associated with poor memory function. This finding may have important implications for the diagnosis and treatment of vitamin B12-related conditions. |
format | Online Article Text |
id | pubmed-6107676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61076762018-08-28 Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance Akkouh, Ibrahim A. Ueland, Torill Andreassen, Ole A. Brattbakk, Hans-Richard Steen, Vidar M. Hughes, Timothy Djurovic, Srdjan Sci Rep Article Memory is indispensable for normal cognitive functioning, and the ability to store and retrieve information is central to mental health and disease. The molecular mechanisms underlying complex memory functions are largely unknown, but multiple genome-wide association studies suggest that gene regulation may play a role in memory dysfunction. We performed a global gene expression analysis using a large and balanced case-control sample (n = 754) consisting of healthy controls and schizophrenia and bipolar disorder patients. Our aim was to discover genes that are differentially expressed in relation to memory performance. Gene expression in blood was measured using Illumina HumanHT-12 v4 Expression BeadChip and memory performance was assessed with the updated California Verbal Learning Test (CVLT-II). We found that elevated expression of the vitamin B12-related gene TCN1 (haptocorrin) was significantly associated with poorer memory performance after correcting for multiple testing (β = −1.50, p = 3.75e-08). This finding was validated by quantitative real-time PCR and followed up with additional analyses adjusting for confounding variables. We also attempted to replicate the finding in an independent case-control sample (n = 578). The relationship between TCN1 expression and memory impairment was comparable to that of important determinants of memory function such as age and sex, suggesting that TCN1 could be a clinically relevant marker of memory performance. Thus, we identify TCN1 as a novel genetic finding associated with poor memory function. This finding may have important implications for the diagnosis and treatment of vitamin B12-related conditions. Nature Publishing Group UK 2018-08-23 /pmc/articles/PMC6107676/ /pubmed/30139959 http://dx.doi.org/10.1038/s41598-018-30898-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Akkouh, Ibrahim A. Ueland, Torill Andreassen, Ole A. Brattbakk, Hans-Richard Steen, Vidar M. Hughes, Timothy Djurovic, Srdjan Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance |
title | Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance |
title_full | Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance |
title_fullStr | Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance |
title_full_unstemmed | Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance |
title_short | Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance |
title_sort | expression of tcn1 in blood is negatively associated with verbal declarative memory performance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107676/ https://www.ncbi.nlm.nih.gov/pubmed/30139959 http://dx.doi.org/10.1038/s41598-018-30898-5 |
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