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Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ

New generation of antibacterial agents are urgently needed in order to fight the emergence of multidrug-resistant bacteria. FtsZ is currently identified as a promising target for new types of antimicrobial compounds development because of its conservative characteristics and its essential role playe...

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Autores principales: Zheng, Yuan-Yuan, Du, Ruo-Lan, Cai, Sen-Yuan, Liu, Zhi-Hua, Fang, Zhi-Yuan, Liu, Ting, So, Lok-Yan, Lu, Yu-Jing, Sun, Ning, Wong, Kwok-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107709/
https://www.ncbi.nlm.nih.gov/pubmed/30174667
http://dx.doi.org/10.3389/fmicb.2018.01937
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author Zheng, Yuan-Yuan
Du, Ruo-Lan
Cai, Sen-Yuan
Liu, Zhi-Hua
Fang, Zhi-Yuan
Liu, Ting
So, Lok-Yan
Lu, Yu-Jing
Sun, Ning
Wong, Kwok-Yin
author_facet Zheng, Yuan-Yuan
Du, Ruo-Lan
Cai, Sen-Yuan
Liu, Zhi-Hua
Fang, Zhi-Yuan
Liu, Ting
So, Lok-Yan
Lu, Yu-Jing
Sun, Ning
Wong, Kwok-Yin
author_sort Zheng, Yuan-Yuan
collection PubMed
description New generation of antibacterial agents are urgently needed in order to fight the emergence of multidrug-resistant bacteria. FtsZ is currently identified as a promising target for new types of antimicrobial compounds development because of its conservative characteristics and its essential role played in bacterial cell division. In the present study, the antibacterial activity of a series of benzofuroquinolinium derivatives was investigated. The results show that the compounds possess potent antibacterial activity against drug resistant pathogens including MRSA, VREF and NDM-1 Escherichia coli. Biological studies reveal that the compound is an effective inhibitor that is able to suppress FtsZ polymerization and GTPase activity and thus stopping the cell division and causing cell death. More importantly, this series of compounds shows low cytotoxicity on mammalian cells and therefore they could be new chemotypes for the development of new antibacterial agents targeting the cell-division protein FtsZ.
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spelling pubmed-61077092018-08-31 Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ Zheng, Yuan-Yuan Du, Ruo-Lan Cai, Sen-Yuan Liu, Zhi-Hua Fang, Zhi-Yuan Liu, Ting So, Lok-Yan Lu, Yu-Jing Sun, Ning Wong, Kwok-Yin Front Microbiol Microbiology New generation of antibacterial agents are urgently needed in order to fight the emergence of multidrug-resistant bacteria. FtsZ is currently identified as a promising target for new types of antimicrobial compounds development because of its conservative characteristics and its essential role played in bacterial cell division. In the present study, the antibacterial activity of a series of benzofuroquinolinium derivatives was investigated. The results show that the compounds possess potent antibacterial activity against drug resistant pathogens including MRSA, VREF and NDM-1 Escherichia coli. Biological studies reveal that the compound is an effective inhibitor that is able to suppress FtsZ polymerization and GTPase activity and thus stopping the cell division and causing cell death. More importantly, this series of compounds shows low cytotoxicity on mammalian cells and therefore they could be new chemotypes for the development of new antibacterial agents targeting the cell-division protein FtsZ. Frontiers Media S.A. 2018-08-17 /pmc/articles/PMC6107709/ /pubmed/30174667 http://dx.doi.org/10.3389/fmicb.2018.01937 Text en Copyright © 2018 Zheng, Du, Cai, Liu, Fang, Liu, So, Lu, Sun and Wong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zheng, Yuan-Yuan
Du, Ruo-Lan
Cai, Sen-Yuan
Liu, Zhi-Hua
Fang, Zhi-Yuan
Liu, Ting
So, Lok-Yan
Lu, Yu-Jing
Sun, Ning
Wong, Kwok-Yin
Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ
title Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ
title_full Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ
title_fullStr Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ
title_full_unstemmed Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ
title_short Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ
title_sort study of benzofuroquinolinium derivatives as a new class of potent antibacterial agent and the mode of inhibition targeting ftsz
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107709/
https://www.ncbi.nlm.nih.gov/pubmed/30174667
http://dx.doi.org/10.3389/fmicb.2018.01937
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