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Double trouble: psoriasis and cardiometabolic disorders

Psoriasis (PsO) is a chronic immune-mediated inflammatory skin disorder associated with numerous co-morbidities. This descriptive review focuses on the cardiometabolic co-morbidities of PsO with reference to the epidemiology and pathogenetic mechanisms linking PsO and cardiometabolic disease (CMD)....

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Autores principales: Nasrin, Goolam Mahyoodeen, Mohammed, Tikly, Nigel, J Crowther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107739/
https://www.ncbi.nlm.nih.gov/pubmed/29293257
http://dx.doi.org/10.5830/CVJA-2017-055
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author Nasrin, Goolam Mahyoodeen
Mohammed, Tikly
Nigel, J Crowther
author_facet Nasrin, Goolam Mahyoodeen
Mohammed, Tikly
Nigel, J Crowther
author_sort Nasrin, Goolam Mahyoodeen
collection PubMed
description Psoriasis (PsO) is a chronic immune-mediated inflammatory skin disorder associated with numerous co-morbidities. This descriptive review focuses on the cardiometabolic co-morbidities of PsO with reference to the epidemiology and pathogenetic mechanisms linking PsO and cardiometabolic disease (CMD). Registry-based studies have shown PsO to be associated with an increased risk of cardiovascular morbidity and mortality. Factors linking PsO and CMD include: chronic inflammation, obesity, classic cardiovascular risk factors, and the effects of systemic therapy used to treat PsO. Chronic inflammation is associated with PsO itself, and with obesity. Adipose tissue is responsible for the secretion of various adipokines, which together with pro-inflammatory cytokines arising from the psoriatic plaque, contribute to the proinflammatory and pro-atherogenic environment. Systemic therapy aimed at decreasing inflammation has been shown to improve CMD in PsO. Screening for and treating CMD and initiating lifestyle modifications will remain the most important interventions until further data emerge regarding the effect of systemic therapy on CMD progression.
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spelling pubmed-61077392018-11-30 Double trouble: psoriasis and cardiometabolic disorders Nasrin, Goolam Mahyoodeen Mohammed, Tikly Nigel, J Crowther Cardiovasc J Afr Review Article Psoriasis (PsO) is a chronic immune-mediated inflammatory skin disorder associated with numerous co-morbidities. This descriptive review focuses on the cardiometabolic co-morbidities of PsO with reference to the epidemiology and pathogenetic mechanisms linking PsO and cardiometabolic disease (CMD). Registry-based studies have shown PsO to be associated with an increased risk of cardiovascular morbidity and mortality. Factors linking PsO and CMD include: chronic inflammation, obesity, classic cardiovascular risk factors, and the effects of systemic therapy used to treat PsO. Chronic inflammation is associated with PsO itself, and with obesity. Adipose tissue is responsible for the secretion of various adipokines, which together with pro-inflammatory cytokines arising from the psoriatic plaque, contribute to the proinflammatory and pro-atherogenic environment. Systemic therapy aimed at decreasing inflammation has been shown to improve CMD in PsO. Screening for and treating CMD and initiating lifestyle modifications will remain the most important interventions until further data emerge regarding the effect of systemic therapy on CMD progression. Clinics Cardive Publishing 2018 /pmc/articles/PMC6107739/ /pubmed/29293257 http://dx.doi.org/10.5830/CVJA-2017-055 Text en Copyright © 2015 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nasrin, Goolam Mahyoodeen
Mohammed, Tikly
Nigel, J Crowther
Double trouble: psoriasis and cardiometabolic disorders
title Double trouble: psoriasis and cardiometabolic disorders
title_full Double trouble: psoriasis and cardiometabolic disorders
title_fullStr Double trouble: psoriasis and cardiometabolic disorders
title_full_unstemmed Double trouble: psoriasis and cardiometabolic disorders
title_short Double trouble: psoriasis and cardiometabolic disorders
title_sort double trouble: psoriasis and cardiometabolic disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107739/
https://www.ncbi.nlm.nih.gov/pubmed/29293257
http://dx.doi.org/10.5830/CVJA-2017-055
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