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Micro-Hotspots of Risk in Urban Cholera Epidemics

Targeted interventions have been delivered to neighbors of cholera cases in major epidemic responses globally despite limited evidence for the impact of such targeting. Using data from urban epidemics in Chad and Democratic Republic of the Congo, we estimate the extent of spatiotemporal zones of inc...

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Autores principales: Azman, Andrew S, Luquero, Francisco J, Salje, Henrik, Mbaïbardoum, Nathan Naibei, Adalbert, Ngandwe, Ali, Mohammad, Bertuzzo, Enrico, Finger, Flavio, Toure, Brahima, Massing, Louis Albert, Ramazani, Romain, Saga, Bansaga, Allan, Maya, Olson, David, Leglise, Jerome, Porten, Klaudia, Lessler, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107744/
https://www.ncbi.nlm.nih.gov/pubmed/29757428
http://dx.doi.org/10.1093/infdis/jiy283
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author Azman, Andrew S
Luquero, Francisco J
Salje, Henrik
Mbaïbardoum, Nathan Naibei
Adalbert, Ngandwe
Ali, Mohammad
Bertuzzo, Enrico
Finger, Flavio
Toure, Brahima
Massing, Louis Albert
Ramazani, Romain
Saga, Bansaga
Allan, Maya
Olson, David
Leglise, Jerome
Porten, Klaudia
Lessler, Justin
author_facet Azman, Andrew S
Luquero, Francisco J
Salje, Henrik
Mbaïbardoum, Nathan Naibei
Adalbert, Ngandwe
Ali, Mohammad
Bertuzzo, Enrico
Finger, Flavio
Toure, Brahima
Massing, Louis Albert
Ramazani, Romain
Saga, Bansaga
Allan, Maya
Olson, David
Leglise, Jerome
Porten, Klaudia
Lessler, Justin
author_sort Azman, Andrew S
collection PubMed
description Targeted interventions have been delivered to neighbors of cholera cases in major epidemic responses globally despite limited evidence for the impact of such targeting. Using data from urban epidemics in Chad and Democratic Republic of the Congo, we estimate the extent of spatiotemporal zones of increased cholera risk around cases. In both cities, we found zones of increased risk of at least 200 meters during the 5 days immediately after case presentation to a clinic. Risk was highest for those living closest to cases and diminished in time and space similarly across settings. These results provide a rational basis for rapidly delivering targeting interventions.
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spelling pubmed-61077442018-08-30 Micro-Hotspots of Risk in Urban Cholera Epidemics Azman, Andrew S Luquero, Francisco J Salje, Henrik Mbaïbardoum, Nathan Naibei Adalbert, Ngandwe Ali, Mohammad Bertuzzo, Enrico Finger, Flavio Toure, Brahima Massing, Louis Albert Ramazani, Romain Saga, Bansaga Allan, Maya Olson, David Leglise, Jerome Porten, Klaudia Lessler, Justin J Infect Dis Major Articles and Brief Reports Targeted interventions have been delivered to neighbors of cholera cases in major epidemic responses globally despite limited evidence for the impact of such targeting. Using data from urban epidemics in Chad and Democratic Republic of the Congo, we estimate the extent of spatiotemporal zones of increased cholera risk around cases. In both cities, we found zones of increased risk of at least 200 meters during the 5 days immediately after case presentation to a clinic. Risk was highest for those living closest to cases and diminished in time and space similarly across settings. These results provide a rational basis for rapidly delivering targeting interventions. Oxford University Press 2018-10-01 2018-05-11 /pmc/articles/PMC6107744/ /pubmed/29757428 http://dx.doi.org/10.1093/infdis/jiy283 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Azman, Andrew S
Luquero, Francisco J
Salje, Henrik
Mbaïbardoum, Nathan Naibei
Adalbert, Ngandwe
Ali, Mohammad
Bertuzzo, Enrico
Finger, Flavio
Toure, Brahima
Massing, Louis Albert
Ramazani, Romain
Saga, Bansaga
Allan, Maya
Olson, David
Leglise, Jerome
Porten, Klaudia
Lessler, Justin
Micro-Hotspots of Risk in Urban Cholera Epidemics
title Micro-Hotspots of Risk in Urban Cholera Epidemics
title_full Micro-Hotspots of Risk in Urban Cholera Epidemics
title_fullStr Micro-Hotspots of Risk in Urban Cholera Epidemics
title_full_unstemmed Micro-Hotspots of Risk in Urban Cholera Epidemics
title_short Micro-Hotspots of Risk in Urban Cholera Epidemics
title_sort micro-hotspots of risk in urban cholera epidemics
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107744/
https://www.ncbi.nlm.nih.gov/pubmed/29757428
http://dx.doi.org/10.1093/infdis/jiy283
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