Chiral (1)H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids

A chiral phosphoric acid promoted enantioselective NMR analysis of atropisomeric quinazolinones was described, in which a variety of racemic arylquinazolinones such as afloqualone and IC-87114 were well recognized with up to 0. 21 ppm ΔΔδ value. With this method, the optical purities of different no...

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Autores principales: Wu, Chaofei, Liu, Hongxin, Li, Juan, Xiao, Hong-Ping, Li, Xinhua, Jiang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107746/
https://www.ncbi.nlm.nih.gov/pubmed/30175093
http://dx.doi.org/10.3389/fchem.2018.00300
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author Wu, Chaofei
Liu, Hongxin
Li, Juan
Xiao, Hong-Ping
Li, Xinhua
Jiang, Jun
author_facet Wu, Chaofei
Liu, Hongxin
Li, Juan
Xiao, Hong-Ping
Li, Xinhua
Jiang, Jun
author_sort Wu, Chaofei
collection PubMed
description A chiral phosphoric acid promoted enantioselective NMR analysis of atropisomeric quinazolinones was described, in which a variety of racemic arylquinazolinones such as afloqualone and IC-87114 were well recognized with up to 0. 21 ppm ΔΔδ value. With this method, the optical purities of different non-racemic substrates can be fast evaluated with high accuracy.
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spelling pubmed-61077462018-08-31 Chiral (1)H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids Wu, Chaofei Liu, Hongxin Li, Juan Xiao, Hong-Ping Li, Xinhua Jiang, Jun Front Chem Chemistry A chiral phosphoric acid promoted enantioselective NMR analysis of atropisomeric quinazolinones was described, in which a variety of racemic arylquinazolinones such as afloqualone and IC-87114 were well recognized with up to 0. 21 ppm ΔΔδ value. With this method, the optical purities of different non-racemic substrates can be fast evaluated with high accuracy. Frontiers Media S.A. 2018-08-17 /pmc/articles/PMC6107746/ /pubmed/30175093 http://dx.doi.org/10.3389/fchem.2018.00300 Text en Copyright © 2018 Wu, Liu, Li, Xiao, Li and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wu, Chaofei
Liu, Hongxin
Li, Juan
Xiao, Hong-Ping
Li, Xinhua
Jiang, Jun
Chiral (1)H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids
title Chiral (1)H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids
title_full Chiral (1)H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids
title_fullStr Chiral (1)H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids
title_full_unstemmed Chiral (1)H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids
title_short Chiral (1)H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids
title_sort chiral (1)h nmr of atropisomeric quinazolinones with enantiopure phosphoric acids
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107746/
https://www.ncbi.nlm.nih.gov/pubmed/30175093
http://dx.doi.org/10.3389/fchem.2018.00300
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