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Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery

The broad substrate capacity of the intestinal oligopeptide transporter, PepT1, has made it a key target of research into drug delivery. Whilst the substrate capacity of this transporter is broad, studies have largely been limited to small peptides and peptide-like drugs. Here, we demonstrate for th...

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Detalles Bibliográficos
Autores principales: Foley, David W., Pathak, Ravindra B., Phillips, Theresa R., Wilson, Gayle L., Bailey, Patrick D., Pieri, Myrtani, Senan, Anish, Meredith, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107785/
https://www.ncbi.nlm.nih.gov/pubmed/30006163
http://dx.doi.org/10.1016/j.ejmech.2018.06.064